1258787-08-4Relevant academic research and scientific papers
Coordination chemistry of amide-functionalised tetraazamacrocycles: Structural, relaxometric and cytotoxicity studies
Martinelli, Jonathan,Balali-Mood, Beeta,Panizzo, Rachael,Lythgoe, Mark F.,White, Andrew J. P.,Ferretti, Patrizia,Steinke, Joachim H. G.,Vilar, Ramon
experimental part, p. 10056 - 10067 (2011/01/09)
Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised. Gadolinium(III) complexes of these three ligands have been prepared as potential monomers for the synthesis of polymeric MRI contrast agents. To assess the potential of these monomers as MRI contrast agents, their relaxation enhancement properties and cytotoxicity have been determined. A europium(III) complex of one of these ligands (with propargyl substituents) is also presented together with its PARACEST properties. In addition, to gain further insight into the coordination chemistry of the tetra-propargyl substituted ligand, the corresponding zinc(II) and cadmium(II) complexes have been prepared. The X-ray crystal structures of the tetra-propargyl ligand and its corresponding gadolinium(III), zinc(II) and cadmium(II) complexes are also presented. The Royal Society of Chemistry 2010.
