1258791-23-9

Basic information

• Product Name: dimethyl 2-(4,5-dimethoxy-2-(phenylethynyl)benzylidene)malonate
• Synonyms: dimethyl 2-(4,5-dimethoxy-2-(phenylethynyl)benzylidene)malonate
• CAS NO: 1258791-23-9
• Molecular Weight: 380.397
• Mol File: 1258791-23-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: dimethyl 2-(4,5-dimethoxy-2-(phenylethynyl)benzylidene)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: dimethyl 2-(4,5-dimethoxy-2-(phenylethynyl)benzylidene)malonate(1258791-23-9)
• EPA Substance Registry System: dimethyl 2-(4,5-dimethoxy-2-(phenylethynyl)benzylidene)malonate(1258791-23-9)

Safety Data

• Hazardous Substances Data: 1258791-23-9(Hazardous Substances Data)

Upstream product

• 61203-53-0 2-iodo-4,5-dimethoxybenzaldehyde 
• 536-74-3 phenylacetylene 
• 106824-46-8 4,5-dimethoxy-2-(2-phenylethynyl)benzaldehyde 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 1258791-15-9 (Z)-dimethyl 1-benzylidene-5,6-dimethoxy-3-(5-methyl-1H-benzo[d]imidazol-1-yl)-1H-indene-2,2(3H)-dicarboxylate 
• 1258791-14-8 (Z)-dimethyl 1-(1H-benzo[d]imidazol-1-yl)-3-benzylidene-5,6-dimethoxy-1H-indene-2,2(3H)-dicarboxylate 
• 1258791-13-7 (Z)-dimethyl 1-benzylidene-3-(1H-imidazol-1-yl)-5,6-dimethoxy-1H-indene-2,2(3H)-dicarboxylate 

Relevant articles and documents

Synthesis of substituted 1,2-dihydroisoquinolinesviaNi(ii) and Cu(i)/Ag(i) catalyzed double nucleophilic addition of arylamines toortho-alkynyl donor-acceptor cyclopropanes (o-ADACs)

A concise approach for the synthesis of substituted 1,2-dihydroisoquinolinesviadouble nucleophilic addition of primary arylamines toortho-alkynyl donor-acceptor cyclopropanes (o-ADACs) in the presence of a catalytic Ni(ClO4)2·6H2O and CuI/AgOTf system has been developed. Further applying this protocol, some of the derived malonates were converted into the corresponding monoesters under Krapcho decarboxylation reaction conditions. Thereafter, these esters were transformed into the respective acids and alcohols. In addition, multifunctionalized 4-(2,2,2-trifluoroacetyl) 1,2-dihydroisoquinolines were also obtained with excess TFAA.