1258792-57-2

Upstream product

• 1258792-36-7 3-(2-bromophenyl)-2-(4-fluorophenyl)-3-oxopropanal 
• 62-53-3 aniline 
• 36282-29-8 2'-bromo-2-(p-fluorophenyl)-acetophenone 
• 352-34-1 4-fluoro-1-iodobenzene 
• 23112-60-9 4-oxo-1-phenyl-1,4-dihydroquinoline-3-carboxylic acid 

Relevant academic research and scientific papers

Palladium-catalyzed decarboxylative coupling of quinolinone-3-carboxylic acids and related heterocyclic carboxylic acids with (Hetero)aryl halides

An efficient and practical decarboxylative cross-coupling reaction of quinolin-4(1H)-one 3-carboxylic acids with (hetero)aryl halides has been established. Under a bimetallic system of PdBr2 and silver carbonate, the protocol proved to be general, and a variety of 3-(hetero)aryl 4-quinolinones and related heterocycles, such as 3-aryl-1,8-naphthyridin-4(1H)- ones, 3-arylcoumarins, 3-arylquinolin-2(1H)-ones, and 2-arylchromones, can be prepared in good to excellent yields.

Metal-free intramolecular amination: One-pot tandem synthesis of 3-substituted 4-quinolones

3-Substituted 4-quinolones were synthesized using a one-pot metal-free strategy in moderate to quantitative yields. Carried out in dimethylsulfoxide (DMSO) via a sequential addition of materials, the methodology is tolerant of a wide range of functional groups and applicable to library synthesis.