23112-60-9

Upstream product

• 1191097-01-4 (Z)-2-(2-chlorobenzoyl)-3-(dimethylamino)acrylic acid methyl ester 
• 205985-98-4 methyl 2-chlorobenzoylacetate 
• 2142-68-9 1-(2-chlorophenyl)ethanone 
• 23112-59-6 ethyl 1,4-dihydro-4-oxo-1-phenyl-3-quinolinecarboxylate 

Downstream Products

• 1258792-41-4 1,3-diphenylquinolin-4(1H)-one 
• 1361247-53-1 C₂₄H₂₁NO₄ 
• 1258792-58-3 3-(4-chlorophenyl)-1-phenylquinolin-4(1H)-one 
• 1258792-57-2 3-(4-fluorophenyl)-1-phenylquinolin-4(1H)-one 
• 1361247-55-3 C₂₂H₁₇NO₂ 
• 1361247-54-2 C₂₅H₁₇NO 
• 1361247-57-5 C₂₁H₁₄FNO 
• 1361247-56-4 C₂₁H₁₄N₂O₃ 
• 1361247-58-6 C₂₄H₁₉NO₃ 
• 1361247-60-0 C₂₄H₁₉NO₃ 
• 1361247-64-4 3-(2-oxo-2H-chromen-3-yl)-1-phenylquinolin-4(1H)-one 
• 1361247-66-6 C₂₆H₂₀N₂O₂ 
• 1361247-52-0 C₂₂H₁₇NO₂ 
• 10258-13-6 1-phenyl-2,3-dihydro-1H-quinolin-4-one 

Relevant academic research and scientific papers

Discovery of novel pyrrolo[2,3-b]pyridine derivatives bearing 4-oxoquinoline moiety as potential antitumor inhibitor

A series of pyrrolo[2,3-b]pyridine derivatives bearing 4-oxoquinoline moiety were designed, synthesized and evaluated for the anti-proliferative on three cancer cell lines (A549, HepG2 and MCF-7) in vitro. Most of the compounds showed moderate to high potency. Some excellent compounds were tested for the inhibitory activity of c-Met kinase. Compound 34 (c-Met IC50 = 17 nM) was investigated the selectivity against Flt-3, c-Kit, VEGFR-2, ALK, PDGFR-β and RON. Structure-activity relationship studies indicated that hydrogen, fluorine atom, and mono-electron-withdrawing groups (mono-EWGs, such as R2 = F) on R, R1 and R2, respectively, were beneficial for the anti-proliferative activities of the target compounds. Besides, we have took further study on the combined mode between compound 34 and c-Met kinase through molecular docking.

Key Structural Elements of Unsymmetrical Cyanine Dyes for Highly Sensitive Fluorescence Turn-On DNA Probes

Unsymmetrical cyanine dyes, such as thiazole orange, are useful for the detection of nucleic acids with fluorescence because they dramatically enhance the fluorescence upon binding to nucleic acids. Herein, we synthesized a series of unsymmetrical cyanine

Picolinamide compound containing triazole or quinolinone structure and application of picolinamide compound

The invention provides a picolinamide compound containing a triazole or quinolinone structure and application of the picolinamide compound. According to a technical scheme in the invention, extensiveresearch is conducted on the picolinamide compound, and

Novel 3-(4-oxo-4h-chromen-2-yl)-(1H)-quinolin-4-one derivatives, method for preparing same and pharmaceutical compositions containing same

Compound of formula (I): wherein: R1, R2, R3, R4, R6, R8, R9 and R10, which may be the same or different, each represent a group selected from hydrogen, hydroxy, alkoxy, alkyl, arylalkoxy, alkoxycarbonylalkoxy and OR′ wherein R′ represents an ionised or ionisable group, R5 represents a group selected from alkyl, aryl and heteroaryl, R7 represents a group selected from hydrogen, hydroxy, alkoxy, alkyl and cycloalkyl, or R7 represents a nitrogen-containing or oxygen-containing heterocycle, its optical isomers, hydrates and solvates thereof and addition salts thereof, with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.