1258846-45-5Relevant academic research and scientific papers
Synthesis and biological evaluation of novel oxazolo[5,4-d]pyrimidines as potent vegfr-2 inhibitors
Deng, Ya-Hui,Xu, Dan,Su, Ye-Xiang,Cheng, Yi-Juan,Yang, Yan-Li,Wang, Xiu-Yun,Zhang, Juan,You, Qi-Dong,Sun, Li-Ping
, p. 528 - 537 (2015)
Tumor angiogenesis is mediated by vascular endothelial growth factor receptor (VEGFR) and other protein kinases. Inhibition of these kinases presents an attractive approach for developing anticancer therapeutics. In this work, a series of 2,5,7-trisubstit
Facile synthesis of 2,5,7-trisubstituted oxazolo[5,4-d]pyrimidines via copper-catalyzed intramolecular C-O bond formation
Xu, Dan,Sun, Li-Ping,You, Qi-Dong
, p. 4248 - 4251 (2012/07/14)
A novel and convenient synthesis of 2,5,7-trisubstituted oxazolo[5,4-d]pyrimidines was presented. The key step involved an intramolecular C-O cross-coupling of the ortho-halopyrimidine amide via a copper (I)-mediated cyclization reaction, which provided t
