1258869-69-0Relevant articles and documents
Synthesis and biological activity of novel 1H-1,4-diazepines containing benzene sulfonyl piperazine moiety
Saingar, Shalini,Kumar, Rajesh,Joshi, Yogesh Chandra
, p. 975 - 980 (2012/05/20)
The synthesis of biologically active 1H-1,4-diazepines 6a-e in good yield, from the heterocyclization reaction of [N4-(4-acetylamino) benzene sulfonyl) piperazinyl- N1-propyl]-1,3-dialkyl/aryl propane-1,3-dione 5a-e and ethylenediamine (EDA) in the presence of silica sulphuric acid (SSA) is described. The novel β-diketones/β-ketoesters 5a-e were synthesized by the condensation reaction of [N4-(4- acetylamino) benzene sulfonyl) piperazinyl-N1-1-bromopropane with various β-diketones/β-ketoesters 4a-e.All structures of the newly synthesized compounds were elucidated by elemental analysis and spectral studies.The compounds 6a-e have been screened for antimicrobial, antifungal and anthelmintic activity. Springer Science+Business Media, LLC 2010.