1258884-17-1

Basic information

• Product Name: (R)-isopropyl 1-(2,3-bis(benzyloxy)propyl)cyclopropane-1-sulfonate
• Synonyms: (R)-isopropyl 1-(2,3-bis(benzyloxy)propyl)cyclopropane-1-sulfonate
• CAS NO: 1258884-17-1
• Molecular Weight: 418.554
• Mol File: 1258884-17-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-isopropyl 1-(2,3-bis(benzyloxy)propyl)cyclopropane-1-sulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-isopropyl 1-(2,3-bis(benzyloxy)propyl)cyclopropane-1-sulfonate(1258884-17-1)
• EPA Substance Registry System: (R)-isopropyl 1-(2,3-bis(benzyloxy)propyl)cyclopropane-1-sulfonate(1258884-17-1)

Safety Data

• Hazardous Substances Data: 1258884-17-1(Hazardous Substances Data)

Upstream product

• 2930-05-4 Benzyloxymethyl-oxiran 
• 146475-51-6 propan-2-yl cyclopropanesulfonate 
• 100-44-7 benzyl chloride 
• 1258884-16-0 (R)-isopropyl 1-(3-(benzyloxy)-2-hydroxypropyl)cyclopropane-1-sulfonate 
• 100-39-0 benzyl bromide 

Downstream Products

• 1258885-12-9 potassium (R)-1-(2,3-bis(benzyloxy)propyl)cyclopropane-1-sulfonate 
• 1258884-18-2 (R)-1-(2,3-bis(benzyloxy)propyl)cyclopropane-1-sulfonyl chloride 
• 1415582-04-5 (R)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide 
• 1259007-43-6 (R)-1-(2,3-bis(benzyloxy)propyl)cyclopropane-1-sulfonic acid 
• 1415582-07-8 (R)-1-(2,3-bis(benzyloxy)propyl)-N-(4,5-difluoro-6-((2-fluoro-4-iodophenyl)amino)benzofuran-7-yl)cyclopropane-1-sulfonamide 

Relevant articles and documents

HETEROCYCLIC SULFONAMIDE DERIVATIVES

The present invention relates to compounds (I) and pharmaceutically acceptable salts thereof. The compounds have been demonstrated as inhibitors of MEK and therefore may be useful in the treatment of hyperproliferative diseases like cancer and inflammation.

NOVEL 6-ARYLAMINO PYRIDONE SULFONAMIDES AND 6-ARYLAMINO PYRAZINONE SULFONAMIDES AS MEK INHIBITORS

The invention provides novel substituted 6-arylamino pyridone sulfonamides and 6 arylamino pyrazinone sulfonamides represented by Formula I, or a pharmaceutically acceptable salt, solvate, polymorph, ester, tautomer or prodrug thereof, and a composition comprising these compounds. The compounds provided can be used as inhibitors of MEK and are useful in the treatment of inflammatory diseases, cancer and other hyperproliferative diseases. The invention further provides a method of treatment for inflammatory diseases, cancer and other hyperproliferative diseases in mammals, especially humans