1258975-64-2Relevant academic research and scientific papers
Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses
Demont, Emmanuel H.,Bailey, James M.,Bit, Rino A.,Brown, Jack A.,Campbell, Colin A.,Deeks, Nigel,Dowell, Simon J.,Eldred, Colin,Gaskin, Pam,Gray, James R. J.,Haynes, Andrea,Hirst, David J.,Holmes, Duncan S.,Kumar, Umesh,Morse, Mary A.,Osborne, Greg J.,Renaux, Jessica F.,Seal, Gail A. L.,Smethurst, Chris A.,Taylor, Simon,Watson, Robert,Willis, Robert,Witherington, Jason
, p. 1003 - 1020 (2016/02/23)
FTY720 is the first oral small molecule approved for the treatment of people suffering from relapsing-remitting multiple sclerosis. It is a potent agonist of the S1P1 receptor, but its lack of selectivity against the S1P3 receptor ha
