1259020-79-5

Basic information

• Product Name: 5-bromo-2-chloro-4-methoxybenzonitrile
• Synonyms: 5-bromo-2-chloro-4-methoxybenzonitrile
• CAS NO: 1259020-79-5
• Molecular Weight: 246.491
• Mol File: 1259020-79-5.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 5-bromo-2-chloro-4-methoxybenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-chloro-4-methoxybenzonitrile(1259020-79-5)
• EPA Substance Registry System: 5-bromo-2-chloro-4-methoxybenzonitrile(1259020-79-5)

Safety Data

• Hazardous Substances Data: 1259020-79-5(Hazardous Substances Data)

Upstream product

• 1259020-46-6 5-bromo-2-chloro-4-hydroxybenzonitrile 
• 77-78-1 dimethyl sulfate 
• 3336-16-1 2-chloro-4-hydroxybenzonitrile 

Downstream Products

• 1259020-48-8 5-bromo-2-chloro-4-methoxybenzoic acid 
• 1033723-31-7 (5-bromo-2-chloro-4-methoxyphenyl)methanol 
• 1259020-50-2 (5-bromo-2-chloro-4-methoxybenzyloxy)triisopropylsilane 
• 1313512-91-2 (2-chloro-4-methoxy-5-((3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)phenyl)methanol 
• 1313512-92-3 (2-chloro-4-methoxy-5-((3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)tetrahydro-2H-pyran-2-yl)benzyloxy)triisopropylsilane 
• 1313512-93-4 2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)acetonitrile 
• 1313512-94-5 C₄₂H₄₂BrClO₆ 
• 1259020-54-6 2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)acetic acid 
• 1313512-98-9 2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)phenyl)-N-(2-(furan-2-yl)-2-oxoethyl)acetamide 
• 1313512-99-0 2-(2-chloro-4-methoxy-5-((2S,3S,4R,5R,6R)-3,4,5-tris(benzyloxy)-6-(benzyloxymethyl)-tetrahydro-2H-pyran-2-yl)benzyl)-5-(furan-2-yl)thiazole 
• 1313513-00-6 (2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-2-yl)thiazol-2-yl)methyl)-2-methoxyphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1313513-01-7 (2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(furan-3-yl)thiazol-2-yl)methyl)-2-methoxyphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol 
• 1313513-02-8 (2S,3R,4R,5S,6R)-2-(4-chloro-5-((5-(thiophen-2-yl)thiazol-2-yl)methyl)-2-methoxyphenyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol 

Relevant articles and documents

Thiazolylmethyl ortho-substituted phenyl glucoside library as novel C-aryl glucoside SGLT2 inhibitors

In order to investigate SAR regarding proximal phenyl ring in novel C-aryl glucoside SGLT2 inhibitors containing a thiazole motif, a series of chemical modifications on proximal phenyl ring was conducted. During a series of lead optimization efforts, orth

THIAZOLE DERIVATIVES AS SGLT2 INHIBITORS AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a novel compound with thiazole ring having an inhibitory activity against sodium-dependent glucose cotransporter 2 (SGLT2) being present in the intestine and kidney, and a pharmaceutical composition comprising the same as an active ingredient, which is useful for preventing or treating metabolic disorders, particularly diabetes.