1259058-89-3Relevant academic research and scientific papers
CuBr/N,N-dimethylglycine-catalyzed coupling reaction of 2-chlorotrifluoroacetanilides with phenols at mild conditions
Hao, Chao,Zhang, Yihua,Jiang, Yongwen,Ma, Dawei
experimental part, p. 1645 - 1650 (2011/06/27)
The ortho-substituent effect directed by the CF3CONH group exists in CuBr/N,N-dimethylglycine-catalyzed diaryl ether formation from o-chlorotrifluoroacetanilides and phenols, leading to this coupling reaction proceeding at 80 °C to afford a wide range of diaryl ethers. The halogen-exchange also plays an important role in this transformation because adding potassium iodide is essential for complete conversion.
