62926-91-4

Upstream product

• 95-51-2 o-chloroaniline 
• 76-05-1 trifluoroacetic acid 
• 407-25-0 trifluoroacetic anhydride 

Downstream Products

• 1119898-20-2 diphenyl[2-(trifluoroacetamido)phenyl]phosphine oxide 
• 13141-38-3 2-phenylethynylaniline 
• 134275-16-4 1-benzyl-2-(trifluoromethyl)-1H-benzo[d]imidazole 
• 143360-89-8 o-(phenylethynyl)trifluoroacetanilide 
• 948-65-2 2-phenyl-indole 
• 2371-29-1 2-((2-chlorophenyl)amino)acetohydrazide 
• 311764-69-9 2,2,2-trifluoro-N-(2-phenoxyphenyl)acetamide 
• 2688-84-8 2-phenoxyaniline 
• 1259059-07-8 2,2,2-trifluoro-N-(2-(isoquinolin-5-yloxy)phenyl)acetamide 
• 1259058-81-5 N-(2-(3-dimethylamino-phenoxy)-phenyl)-2,2,2-trifluoroacetamide 
• 1259058-83-7 N-(2-(3,5-dimethyl-phenoxy)-phenyl)-2,2,2-trifluoroacetamide 
• 1259058-73-5 2,2,2-trifluoro-N-(2-(naphthalen-2-yloxy)-phenyl)acetamide 
• 1259058-89-3 2,2,2-trifluoro-N-(2-(2-methoxy-phenoxy)-phenyl)acetamide 
• 1259058-66-6 2,2,2-trifluoro-N-(2-(4-methoxy-phenoxy)-phenyl)acetamide 

Relevant academic research and scientific papers

Design, Synthesis, and Evaluation of the Highly Selective and Potent G-Protein-Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure

A novel class of therapeutic drug candidates for heart failure, highly potent and selective GRK2 inhibitors, exhibit potentiation of β-adrenergic signaling in vitro studies. Hydrazone derivative 5 and 1,2,4-triazole derivative 24a were identified as hit compounds by HTS. New scaffold generation and SAR studies of all parts resulted in a 4-methyl-1,2,4-triazole derivative with an N-benzylcarboxamide moiety with highly potent activity toward GRK2 and selectivity over other kinases. In terms of subtype selectivity, these compounds showed enough selectivity against GRK1, 5, 6, and 7 with almost equipotent inhibition to GRK3. Our medicinal chemistry efforts led to the discovery of 115h (GRK2 IC50 = 18 nM), which was obtained the cocrystal structure with human GRK2 and an inhibitor of GRK2 that potentiates β-adrenergic receptor (βAR)-mediated cAMP accumulation and prevents internalization of βARs in β2AR-expressing HEK293 cells treated with isoproterenol. Therefore, 115h appears to be a novel class of therapeutic for heart failure treatment.

A one-pot procedure for trifluoroacetylation of arylamines using trifluoroacetic acid as a trifluoroacetylating reagent

A convenient procedure for the preparation of aryl trifluoroacetamides from aryl amines is described that employs 2-4 M equiv of trifluoroacetic acid in refluxing xylene as a trifluoroacetylating agent. Addition of an amount of pyridine that is equimolar to the amount of trifluoroacetic acid present in the reaction mixture facilitates the trifluoroacetylation of rather basic arylamines.

Trifluoroacetylation of arylamines using poly-phosphoric acid trimethylsilylester (PPSE)

A new, simple and useful procedure is described for the trifluoroacetylation of arylamines using trifluoroacetic acid and poly-phosphoric acid trimethylsilylester (PPSE) as the condensation agent.

Novel diarylsulfonylurea derivatives as potent antimitotic agents

Novel diarylsulfonylurea derivatives have been synthesized and identified as potent inhibitors of tubulin polymerization and cancer cell proliferation. Furthermore, these compounds were also efficacious against multidrug-resistant cancer cells. A novel series of diarylsulfonylurea derivatives were synthesized and evaluated for interaction with tubulin and for cytotoxicity against human cancer cell lines. These derivatives demonstrated good inhibitory activity against tubulin polymerization, which was well correlated with promising antiproliferative activity as well as G2/M phase cell cycle arrest. Furthermore, several compounds were also efficacious against multidrug-resistant cancer cells, which are resistant to many other known microtubule inhibitors.

Direct microwave promoted trifluoroacetylation of aromatic amines with trifluoroacetic acid

A simple microwave-promoted procedure has been developed for the direct preparation of trifluoroacetanilides. An equimolar mixture of substituted anilines and trifluoroacetic acid was microwave irradiated at short reaction times, giving the corresponding anilides in high yields and purity.