125926-53-6

Basic information

• Product Name: 1-((4-fluorophenyl)sulfonyl)-4-Methylpiperazine
• Synonyms: 1-((4-fluorophenyl)sulfonyl)-4-Methylpiperazine
• CAS NO: 125926-53-6
• Molecular Formula: C₁₁H₁₅FN₂O₂S
• Molecular Weight: 258.3124032
• Mol File: 125926-53-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-((4-fluorophenyl)sulfonyl)-4-Methylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-((4-fluorophenyl)sulfonyl)-4-Methylpiperazine(125926-53-6)
• EPA Substance Registry System: 1-((4-fluorophenyl)sulfonyl)-4-Methylpiperazine(125926-53-6)

Safety Data

• Hazardous Substances Data: 125926-53-6(Hazardous Substances Data)

Usage

General Description

1-((4-fluorophenyl)sulfonyl)-4-Methylpiperazine, also known as GF-120918, is a chemical compound that belongs to the class of piperazine derivatives. It is a selective inhibitor of the multidrug resistance-associated protein (MRP1) and P-glycoprotein, which are involved in multi-drug resistance in cancer cells. 1-((4-fluorophenyl)sulfonyl)-4-Methylpiperazine has shown promise in reversing drug resistance in cancer treatment by blocking the efflux of chemotherapeutic agents from cancer cells. Additionally, 1-((4-fluorophenyl)sulfonyl)-4-Methylpiperazine has also been studied for its potential use in treating other diseases involving drug resistance, such as epilepsy and HIV infection. Further research is ongoing to explore its full therapeutic potential and possible applications in medical treatment.

Upstream product

• 837-12-7 1-((4-bromophenyl)sulfonyl)-4-methylpiperazine 
• 109-01-3 1-methyl-piperazine 
• 349-88-2 4-Fluorobenzenesulfonyl chloride 

Downstream Products

• 1177419-88-3 1-{[4-(3-[(1S)-2-Methoxy-1-methylethoxy]-5-{5-[(5S)-5-methyl-4,5-dihydro-1,3-oxazol-2-yl]-1H-pyrrol-2-yl}phenoxy)phenyl]sulfonyl}-4-methylpiperazine 
• 1177419-89-4 (2S)-2-(3-{5-[(5S)-5-Methyl-4,5-dihydro-1,3-oxazol-2-yl]-1H-pyrrol-2-yl}-5-{4-[(4-methylpiperazin-1-yl)sulfonyl]phenoxy}phenoxy)propan-1-ol 
• 1160182-50-2 N,N-diethyl-4-(1-hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yloxy)benzenesulfonamide 
• 1160182-51-3 5-(4-(4-methylpiperazin-1-ylsulfonyl)phenoxy)benzo[c][1,2]oxaborol-1(3H)-ol 
• 1160182-49-9 C₁₈H₁₉BrN₂O₄S 
• 1187189-87-2 C₂₀H₂₃BrN₂O₅S 
• 125903-43-7 1-<<4-(1H-imidazol-1-yl)phenyl>benzenesulfonyl>-4-methylpiperazine 

Relevant articles and documents

A Fluorinated Ligand Enables Room-Temperature and Regioselective Pd-Catalyzed Fluorination of Aryl Triflates and Bromides

A new biaryl monophosphine ligand (AlPhos, L1) allows for the room-temperature Pd-catalyzed fluorination of a variety of activated (hetero)aryl triflates. Furthermore, aryl triflates and bromides that are prone to give mixtures of regioisomeric aryl fluorides with Pd-catalysis can now be converted to the desired aryl fluorides with high regioselectivity. Analysis of the solid-state structures of several Pd(II) complexes, as well as density functional theory (DFT) calculations, shed light on the origin of the enhanced reactivity observed with L1.

NOVEL PHENYLPYRROLE DERIVATIVE

The present invention relates to a compound or a pharmacologically acceptable salt thereof having superior glucokinase activating activity, and is a compound represented by general formula (I), or pharmacologically acceptable salt thereof: [wherein, A represents, for example, an oxygen atom or sulfur atom, R1 represents, for example, a C1-C6 alkyl group, a C1-C6 alkoxy group or a C1-C6 halogenated alkyl group, A and R1 together with the carbon atom bonded thereto form a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R2 represents a phenyl group that may be substituted with 1 to 5 group(s) independently selected from Substituent Group α or a heterocyclic group that may be substituted with 1 to 3 group(s) independently selected from Substituent Group α, R3 represents a hydroxy group or a C1-C6 alkoxy group, and Substituent Group α consists of, for example, a halogen atom, a C1-C6 alkyl group, a C1-C6 alkyl group substituted with 1 or 2 hydroxy group(s), a C1-C6 alkylsulfonyl group, and a group represented by the formula -V-NR5R6 (wherein, V represents a carbonyl group or a sulfonyl group, and R5 and R6 may be the same or different and respectively represent a hydrogen atom or a C1-C6 alkyl group, or R5 and R6 together with the nitrogen atom bonded thereto form a 4- to 6-membered saturated heterocycle that may be substituted with 1 or 2 group(s) independently selected from a C1-C6 alkyl group and a hydroxy group, and the 4- to 6-membered saturated heterocycle may further contain one oxygen atom or nitrogen atom)].