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CAS

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1259287-87-0

Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate

    Cas No: 1259287-87-0

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  • 1259287-87-0 Structure

  • Basic information

    1. Product Name: Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate
    2. Synonyms: Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate
    3. CAS NO:1259287-87-0
    4. Molecular Formula: C14H19NO3S
    5. Molecular Weight: 281.37056
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1259287-87-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate(CAS DataBase Reference)
    10. NIST Chemistry Reference: Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate(1259287-87-0)
    11. EPA Substance Registry System: Methyl 6-pivaloyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-2-carboxylate(1259287-87-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1259287-87-0(Hazardous Substances Data)

1259287-87-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1259287-87-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,9,2,8 and 7 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1259287-87:
(9*1)+(8*2)+(7*5)+(6*9)+(5*2)+(4*8)+(3*7)+(2*8)+(1*7)=200
200 % 10 = 0
So 1259287-87-0 is a valid CAS Registry Number.

1259287-87-0Downstream Products

1259287-87-0Relevant articles and documents

Potent histone deacetylase inhibitors derived from 4-(aminomethyl)-N- hydroxybenzamide with high selectivity for the HDAC6 isoform

Blackburn, Christopher,Barrett, Cynthia,Chin, Janice,Garcia, Kris,Gigstad, Kenneth,Gould, Alexandra,Gutierrez, Juan,Harrison, Sean,Hoar, Kara,Lynch, Chrissie,Rowland, R. Scott,Tsu, Chris,Ringeling, John,Xu, He

, p. 7201 - 7211 (2013/10/21)

A screen for HDAC6 inhibitors identified acyl derivatives of 4-(aminomethyl)-N-hydroxybenzamide as potent leads with unexpected selectivity over the other subtypes. We designed and synthesized constrained heterocyclic analogues such as tetrahydroisoquinolines that show further enhanced HDAC6 selectivity and inhibitory activity in cellular assays. Selectivity may be attributed to the benzylic spacer more effectively accessing the wider channel of HDAC6 compared to other HDAC subtypes as well as hydrophobic capping groups interacting with the protein surface near the rim of the active site.

SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF

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Page/Page column 100, (2011/01/12)

This invention provides compounds of formula (/): wherein R1, R2, G, n, p and q have values as described in the specification, useful as inhibitors of HDAC6. The invention also provides pharmaceutical compositions comprising the comp

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