1259300-25-8

Basic information

• Product Name: 2-(4-(tert-butyl)phenyl)quinazoline
• Synonyms: 2-(4-(tert-butyl)phenyl)quinazoline
• CAS NO: 1259300-25-8
• Molecular Weight: 262.354
• Mol File: 1259300-25-8.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2-(4-(tert-butyl)phenyl)quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-(tert-butyl)phenyl)quinazoline(1259300-25-8)
• EPA Substance Registry System: 2-(4-(tert-butyl)phenyl)quinazoline(1259300-25-8)

Safety Data

• Hazardous Substances Data: 1259300-25-8(Hazardous Substances Data)

Upstream product

• 1710-98-1 p-tert-butyl benzoyl chloride 
• 4210-32-6 4-tert-butyl benzonitrile 
• 100-46-9 benzylamine 
• 5344-90-1 2-Aminobenzyl alcohol 
• 877-65-6 p-tert-butylbenzyl alcohol 
• 4403-69-4 2-amino-1-benzylamine 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 201230-82-2 carbon monoxide 
• 1514933-76-6 2-(4-tert-butylphenyl)-1,2,3,4-tetrahydroquinazoline 
• 939-97-9 4-tert-Butylbenzaldehyde 
• 56108-12-4 4-tert-butylbenzamide 

Downstream Products

• 1451359-73-1 (E)-2-(4-(tert-butyl)phenyl)-4-styrylquinazoline 

Relevant articles and documents

Electrochemical Acceptorless Dehydrogenation of N-Heterocycles Utilizing TEMPO as Organo-Electrocatalyst

Catalytic acceptorless dehydrogenation (CAD) has been a basically important organic transformation to ubiquitous unsaturated compounds without the usage of a sacrificial hydrogen acceptor. In this work, we successfully developed the first electrochemical acceptorless dehydrogenation (ECAD) of N-heterocycles using TEMPO as the organo-electrocatalyst. We have achieved the catalytic dehydrogenation of N-heterocycles in an anode and the release of H2 in a cathode using an undivided-cell system. A variety of six-membered and five-membered nitrogen-heteroarenes can be synthesized in good yields in this system. In addition, this protocol can also be used in the application of important molecular synthesis. Our electrochemical strategy provides a mild and metal-free route for (hetero)aromatic compounds synthesis via the CAD strategy.

Nickel-Catalyzed [4 + 2] Annulation of Nitriles and Benzylamines by C-H/N-H Activation

Nickel-catalyzed [4 + 2] annulation of benzylamines and nitriles via C-H/N-H bond activation, providing straightforward atom-economic access to a wide variety of multisubstituted quinazolines, is reported. Mechanistic investigation revealed that the in situ formed amidines from the coupling of benzylamines and nitriles direct the nickel catalyst to activate the ortho-C-H bond of the phenyl ring of the benzylamine.

Dehydrogenative Synthesis of Quinolines, 2-Aminoquinolines, and Quinazolines Using Singlet Diradical Ni(II)-Catalysts

Simple, straightforward, and atom economic methods for the synthesis of quinolines, 2-aminoquinolines, and quinazolines via biomimetic dehydrogenative condensation/coupling reactions, catalyzed by well-defined inexpensive and easy to prepare singlet diradical Ni(II)-catalysts featuring two antiferromagnetically coupled singlet diradical diamine type ligands are described. Various polysubstituted quinolines, 2-aminoquinolines, and quinazolines were synthesized in moderate to good yields from different low-cost and readily accessible starting materials. Several control experiments were carried out to get insight into the reaction mechanism which shows that the nickel and the coordinated diamine ligands participate in a synergistic way during the dehydrogenation of alcohols.