1259305-29-7 Usage
Description
Aripiprazole
lauroxil is a long acting injectable (LAI) pro-drug formulation
of aripiprazole approved in the U.S. for the treatment of
schizophrenia. Aripiprazole lauroxil is a dopamine D2
receptor partial antagonist, a 5-HT2A antagonist, and a 5-
HT1A partial agonist that was developed by Alkermes. It was Aripiprazole
lauroxil is a long acting injectable (LAI) pro-drug formulation
of aripiprazole approved in the U.S. for the treatment of
schizophrenia.28 Aripiprazole lauroxil is a dopamine D2
receptor partial antagonist, a 5-HT2A antagonist, and a 5-
HT1A partial agonist that was developed by Alkermes. It was
Definition
ChEBI: A dodecanoate ester obtained by formal condensation of the carboxy group of dodecanoic acid with the hydroxy group of 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-2-oxo-3,4-dihydroquinolin-1(2H)-yl]methanol. A prodrug for aripipraz
le, it is used for treatment of schizophrenia.
Synthesis
The synthesis of aripiprazole lauroxil has only been described
on gram scale in the patent literature. Commercially available aripiprazole (58) was
treated with formaldehyde to give hemiaminal 59 in 65% crude
yield and was then heated with lauric anhydride to give
aripiprazole lauroxil (VII) in 21% overall yield.
Check Digit Verification of cas no
The CAS Registry Mumber 1259305-29-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,5,9,3,0 and 5 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 1259305-29:
(9*1)+(8*2)+(7*5)+(6*9)+(5*3)+(4*0)+(3*5)+(2*2)+(1*9)=157
157 % 10 = 7
So 1259305-29-7 is a valid CAS Registry Number.
1259305-29-7Relevant articles and documents
PROCESS FOR THE PREPARATION OF ARIPIPRAZOLE LAUROXIL
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Page/Page column 11; 12; 13, (2021/02/12)
It is provided a process for the preparation of aripiprazole lauroxil that comprises reacting l-(hydroxymethyl) aripiprazole with lauric anhydride in the presence of DMAP and a solvent.
Lauroyl aripiprazole preparation method
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Paragraph 0012; 0013, (2020/03/06)
The invention relates to a synthetic method of a chemical drug lauroyl aripiprazole (represented by a formula I), wherein lauroyl aripiprazole is prepared by using aripiprazole through a two-step reaction. The formula I is defined in the specification.
PROCESS FOR THE PREPARATION OF ARIPIPRAZOLE LAUROXIL
-
Page/Page column 15; 16, (2019/02/13)
It is provided a process for the preparation of aripiprazole lauroxil that comprises reacting 1-(hydroxymethyl) aripiprazole with lauric acid in the presence of a suitable solvent and a carboxyl activating agent in the presence of a suitable solventand, o
