1259320-13-2Relevant academic research and scientific papers
Metal-free synthesis of 2-fluoroalkylated quinolines using polyfluoroalkanoic acids as direct fluorine sources
Nan, Jiang,Hu, Yan,Chen, Pu,Ma, Yangmin
, p. 1984 - 1988 (2019)
A novel [5 + 1] cyclization of 2-vinylanilines with polyfluoroalkanoic acids under catalyst- A nd additive-free conditions was successfully implemented. The approach directly employs very low-cost and readily available polyfluoroalkanoic acids as both C1 synthons and fluoroalkyl building blocks. This method provides concise access to diverse 2-fluoroalkylated (CF3, C2F5, C3F7, CF2H, CF2Cl, and CF2Br) quinolines in good yields with excellent functional group tolerance in high yield on a gram scale.
An efficient synthesis of 2-trifluoromethyl quinolines via gold-catalyzed cyclization of trifluoromethylated propargylamines
Zhu, Mei,Fu, Weijun,Zou, Guanglong,Xun, Chen,Deng, Dongsheng,Ji, Baoming
experimental part, p. 195 - 199 (2012/04/04)
A highly efficient cyclization reaction of trifluoromethylated propargylamines leading to 2-trifluoromethyl-4-aryl quinolines was developed by using gold(I) as a catalyst under extremely mild conditions.
