1259374-83-8

Basic information

• Product Name: tert-butyl 5-(4-methoxyphenyl)-2-phenyl-thiazole-4-carboxylate
• Synonyms: tert-butyl 5-(4-methoxyphenyl)-2-phenyl-thiazole-4-carboxylate
• CAS NO: 1259374-83-8
• Molecular Weight: 367.469
• Mol File: 1259374-83-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: tert-butyl 5-(4-methoxyphenyl)-2-phenyl-thiazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 5-(4-methoxyphenyl)-2-phenyl-thiazole-4-carboxylate(1259374-83-8)
• EPA Substance Registry System: tert-butyl 5-(4-methoxyphenyl)-2-phenyl-thiazole-4-carboxylate(1259374-83-8)

Safety Data

• Hazardous Substances Data: 1259374-83-8(Hazardous Substances Data)

Upstream product

• 1446782-74-6 C₂₃H₂₆N₂O₃S 
• 1446781-98-1 t-butyl 2-benzamido-3-(4-methoxyphenyl)-3-(methylthio)acrylate 
• 1446782-78-0 4-[(4-methoxyphenyl)(methylthio)methylene]-2-phenyloxazol-5(4H)-one 
• 591-50-4 iodobenzene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 1037746-91-0 tert-butyl 1,3-thiazole-4-carboxylate 

Relevant articles and documents

Synthesis of 2,4,5-trisubstituted thiazoles via lawesson's reagent-mediated chemoselective thionation-cyclization of functionalized enamides

An efficient route to 2-phenyl/(2-thienyl)-5-(het)aryl/(methylthio)-4- functionalized thiazoles via one-step chemoselective thionation-cyclization of highly functionalized enamides mediated by Lawesson's reagent is reported. These enamide precursors are obtained by nucleophilic ring-opening of 2-phenyl/(2-thienyl)-4-[bis(methylthio)/(methylthio)(het)arylmethylene] -5-oxazolones with alkoxides and a variety of primary aromatic/aliphatic amines or amino acid esters, leading to the introduction of an ester, an N-substituted carboxamide, or a peptide functionality in the 4-position of the product thiazoles.

Carbonates: Eco-friendly solvents for palladium-catalysed direct arylation of heteroaromatics

The palladium-catalysed direct 2-, 4- or 5-arylation of a wide range of heteroaromatics with aryl halides proceed in moderate to good yields using the eco-friendly solvents carbonates. The best yields were obtained using benzoxazole or thiazole derivatives. The arylation of furan, thiophene, pyrrole, imidazole or isoxazole derivatives was found to require a more elevated reaction temperature. The Royal Society of Chemistry 2010.