1259401-76-7Relevant academic research and scientific papers
With anti-HIV active 3 - amino propionic acid piperidine amide compound, synthetic method and use
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Paragraph 0155; 0156, (2017/08/25)
The invention relates to a 3-aminopropionic acid piperidine amide compound as shown in formula I, and its pharmaceutically acceptable salts or solvates, wherein the substituents are defined in claims; the invention also relates to a preparation method of the compound, pharmaceutical compositions containing the compound, the salts or solvates, and applications in preparation of drugs for treating HIV infection related diseases and symptoms.
AMINE COMPOUNDS AND USE THEREOF
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Page/Page column 51, (2010/02/12)
It is intended to provide novel amine compounds which are efficacious against diseases such as infection with HIV virus, rheumatism and cancer metastasis. Namely, amine compounds represented by the following general formula (1):In a typical case, A1 and A2 represent each an optionally substituted monocyclic or polycyclic aromatic heterocycle; W represents cyclic C3-10 alkylene, an optionally substituted monocyclic or polycyclic aromatic heterocycle, a monocyclic or polycyclic aromatic ring or a partly saturated polycyclic aromatic ring; X represents O, CH2, C(=O) or NR11; and D is a group represented by the following general formula (4) or (6).-Q-Y-BIn the formula (6), Q represents a single bond, S, O or NR12; and Y is a group represented by the following general formula (7). z represents an optionally substituted monocyclic or polycyclic aromatic ring. In the formula (6), B represents NR25R26. In the above formulae, R1 to R26 each represents hydrogen, alkyl, alkenyl or alkynyl.
