1259488-13-5Relevant academic research and scientific papers
Chiral Bronsted acid-catalyzed enantioselective friedel-crafts reaction of 4,7-dihydroindoles with trifluoromethyl ketones
Wang, Teng,Zhang, Guang-Wu,Teng, Yuou,Nie, Jing,Zheng, Yan,Ma, Jun-An
scheme or table, p. 2773 - 2777 (2010/12/25)
In the presence of chiral phosphoric acid, an enantioselective Friedel-Crafts reaction of 4,7-dihydroindoles with aromatic trifluoromethyl ketones and ethyl 4,4,4-trifluoroacetoacetate has been realized. A series of 2-substituted 4,7-dihydroindoles with a trifluoromethylated tertiary alcohol moiety were obtained in 45-95% yields with 60-93% ee. Furthermore, 2-functionalized indole derivatives could be produced through a one-pot process.
