1259511-45-9Relevant academic research and scientific papers
Carboxylation of N-H/C-H bonds using n-heterocyclic carbene copper(I) complexes
Boogaerts, Ine I. F.,Fortman, George C.,Furst, Marc R. L.,Cazin, Catherine S. J.,Nolan, Steven P.
, p. 8674 - 8677 (2010)
Greenhouse gas makes good: A simple copper-mediated protocol has been developed where N-H or C-H bonds can be directly functionalized using an easily prepared catalyst. The novel [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene] copper(I) hydroxide, [Cu(IPr)(OH)], permits the facile activation and carboxylation of N-H and C-H bonds with pKavalues of less than 27.7 (see scheme).
CARBOXYLATION CATALYSTS
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Paragraph 0099, (2013/04/13)
The use of a complex of the form Z—M—OR in the carboxylation of a substrate is described. The group Z is a two-electron donor ligand, M is a metal and OR is selected from the group consisting of OH, alkoxy and aryloxy. The substrate may be carboxylated at a C—H or N—H bond. The metal M may be copper, silver or gold. The two-electron donor ligand may be a phosphine, a carbene or a phosphite ligand. Also described are methods of manufacture of the complexes and methods for preparing isotopically labelled caboxylic acids and carboxylic acid derivatives.
