1259541-22-4Relevant academic research and scientific papers
Conformationally restricted peptide mimetics by ring-closing olefin metathesis
Wakchaure, Satish,Einsiedel, Juergen,Waibel, Reiner,Gmeiner, Peter
, p. 2682 - 2694 (2012)
Elegant chemical methodology restricting the backbone flexibility of biologically active peptides has attracted growing interest. A practical synthetic strategy is presented to access ten-membered lactam peptide mimetics. Employing a ring-closing olefin metathesis as the key reaction step, the cyclic olefin moiety was obtained with cis configuration. Conformational investigations were performed with two model peptides. Georg Thieme Verlag Stuttgart New York.
