125961-06-0Relevant articles and documents
Novel phenoxyalkylamine derivatives. VII. Synthesis and pharmacological activities of 2-alkoxy-5-[(phenoxyalkylamino)alkyl]benzenesulfonamide derivatives
Sakurai,Mitani,Hashimoto,Morikawa,Yasuda,Koshinaka,Kato,Ito
, p. 1443 - 1451 (2007/10/02)
To find a novel α-blocker with high α-blocking selectivity against dopamine D2-receptor affinity, we performed structural modification of the alkylene chains and the substituents on two benzene rings of 2-alkoxy-5-[(phenoxyalkylamino)alkyl]benzenesulfonamide derivatives. The modification of the alkylene chain between the amino moiety in the center of the molecule and the benzene ring (ring A) was found to be the most significant. 5-[2-[[2-(5-Fluoro-2-methoxyphenoxy)ethyl]amino]propyl]-2-methoxybenze nesulfonamide (II-4), which possesses 1-methylethyl as the alkylene chain, exhibited high α-blocking selectivity as well as potent α-blocking activity.
PHENOXYETHYLAMINE DERIVATIVES, FOR PREPARING THE SAME AND COMPOSITION FOR EXHIBITING EXCELLENT ALPHA1-BLOCKING ACTIVITY CONTAINING THE SAME
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, (2008/06/13)
Phenoxyethylamine derivatives represented by the general formula (I): STR1 wherein R 1 and R 5 represent lower-alkyl, R 2 and R. sub.3, which may be the same or different, each represents hydrogen or lower-alkyl, or STR2 represents a 5-or 6-membered ring
