125983-34-8 Usage
Description
2-(CHLOROMETHYL)-1H-PERIMIDINE HYDROCHLORIDE, also known as chlormethine hydrochloride, is a nitrogen mustard alkylating agent used in the treatment of certain types of cancer. It works by interfering with the DNA of cancer cells, causing them to die. This chemical compound is administered through intravenous infusion and is often used in combination with other chemotherapy drugs.
Uses
Used in Oncology:
2-(CHLOROMETHYL)-1H-PERIMIDINE HYDROCHLORIDE is used as an anticancer agent for the treatment of specific types of cancer, such as Hodgkin's disease and non-Hodgkin's lymphoma. It is effective due to its ability to disrupt the DNA of cancer cells, leading to their death.
Used in Combination Chemotherapy:
In the field of oncology, 2-(CHLOROMETHYL)-1H-PERIMIDINE HYDROCHLORIDE is used as a component in combination chemotherapy regimens to enhance the therapeutic effects and increase the chances of remission in cancer patients.
Used in Pharmaceutical Formulation:
2-(CHLOROMETHYL)-1H-PERIMIDINE HYDROCHLORIDE is used as an active pharmaceutical ingredient in the formulation of cancer treatment drugs, where it contributes to the overall efficacy of the medication.
It is crucial to handle and administer 2-(CHLOROMETHYL)-1H-PERIMIDINE HYDROCHLORIDE with extreme caution due to its potential to cause severe skin and eye irritation, and its harmful effects if ingested or inhaled. Additionally, it may have adverse effects on reproductive health and fetal development, necessitating careful consideration by healthcare professionals and patients during its use.
Check Digit Verification of cas no
The CAS Registry Mumber 125983-34-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,5,9,8 and 3 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 125983-34:
(8*1)+(7*2)+(6*5)+(5*9)+(4*8)+(3*3)+(2*3)+(1*4)=148
148 % 10 = 8
So 125983-34-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H9ClN2/c13-7-11-14-9-5-1-3-8-4-2-6-10(15-11)12(8)9/h1-6H,7H2,(H,14,15)
125983-34-8Relevant articles and documents
Synthesis of some benzotriazole-substituted perimidines
Mobinikhaledi,Foroughifar,Goli
, p. 2549 - 2554 (2005)
2-substituted perimidines 3(a-g) were prepared from an acid-catalyzed reaction of 1,8-diaminonaphthalene with carboxylic acids using microwave irradiation. Addition of these perimidines to 1-chloromethyl benzotriazole in the presence of the sodium amide under reflux conditions gave benzotriazole-substituted perimidines 5(a-f). Yields of these products following recrystallization from water were of the order of 60-65%. IR and 1HNMR spectra and elemental analysis were used for identification of these compounds. Copyright Taylor & Francis Inc.
