1259874-80-0

Basic information

• Product Name: C₂₈H₃₀N₃O₁₁P
• CAS NO: 1259874-80-0
• Molecular Weight: 615.533
• Mol File: 1259874-80-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₈H₃₀N₃O₁₁P(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₈H₃₀N₃O₁₁P(1259874-80-0)
• EPA Substance Registry System: C₂₈H₃₀N₃O₁₁P(1259874-80-0)

Safety Data

• Hazardous Substances Data: 1259874-80-0(Hazardous Substances Data)

Upstream product

• 51549-50-9 5'-O-tert-butyldimethylsilyl-3'-O,4-N-dibenzoyl-2'-deoxycytidine 
• 951-77-9 2'-Deoxycytidine 
• 51549-27-0 β-D-5'-O-tert-butyldimethylsilyl-2'-deoxycytidine 
• 60190-78-5 methyl 2-diazo-2-(dimethoxyphosphoryl)acetate 
• 51549-49-6 N-benzoyl-2'-deoxycytidine 3'-benzoate 

Relevant articles and documents

Design and synthesis of α-carboxy phosphononucleosides

Rhodium catalyzed O-H insertion reactions employing α- diazophosphonate 20 with appropriately protected thymidine, uridine, cytosine, adenosine and guanosine derivatives leads to novel 5′-phosphononucleoside derivatives. Deprotection led to a novel series of phosphono derivatives bearing a carboxylic acid moiety adjacent to the phosphonate group with potential antiviral and/or anticancer activity. The phosphononucleosides bearing an α-carboxylic acid group are envisaged as potential diphosphate mimics. Conversion to mono- and diphosphorylated phosphononucleosides has been effected for evaluation as nucleoside triphosphate mimics. Most of the novel phosphononucleosides proved to be inactive against a variety of DNA and RNA viruses. Only the phosphono AZT derivatives 56-59 showed weak activity against HIV-1 and HIV-2.