1259933-15-7

Basic information

• Product Name: (R)-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]-benzodioxole-7,3'-indol]-2'(1'H)-one
• CAS NO: 1259933-15-7
• Molecular Weight: 429.352
• Mol File: 1259933-15-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]-benzodioxole-7,3'-indol]-2'(1'H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]-benzodioxole-7,3'-indol]-2'(1'H)-one(1259933-15-7)
• EPA Substance Registry System: (R)-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]-benzodioxole-7,3'-indol]-2'(1'H)-one(1259933-15-7)

Safety Data

• Hazardous Substances Data: 1259933-15-7(Hazardous Substances Data)

Upstream product

• 1467104-83-1 (3S)-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1-{[5-(trifluoromethyl)furan-2-yl]methyl}-1,3-dihydro-2H-indol-2-one 
• 1286255-36-4 3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-bis(hydroxymethyl)-1,3-dihydro-2H-indol-2-one 
• 1019771-90-4 3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one 
• 1019771-89-1 3-hydroxy-3-(6-hydroxy-1,3-benzodioxol-5-yl)-1,3-dihydro-2H-indol-2-one 
• 912656-46-3 6’H-spiro[indoline-3,7’-[1,3]dioxolo[4,5-f]benzofuran]-2-one 
• 91-56-5 indole-2,3-dione 
• 533-31-3 Sesamol 
• 912661-88-2 1'-{[5-(trifluoromethyl)furan-2-yl]methyl}spiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one 

Relevant articles and documents

The First Asymmetric Pilot-Scale Synthesis of TV-45070

TV-45070 is a small-molecule lactam containing a chiral spiro-ether that has been reported as a potential topical therapy for pain associated with the Nav1.7 sodium ion channel encoded by the gene SCN9A. A pilot-scale synthesis is presented that is highlighted by an asymmetric aldol coupling at ambient temperature, used to create a quaternary chiral center. Although only a moderate ee is obtained, the removal of the undesired isomer is achieved through preferential precipitation of a near racemic mixture from the reaction, leaving the enantiopure isomer in solution. Cyclization to form the final API uses an uncommon diphenylphosphine-based leaving group which proved successful on the neopentyl system when other traditional leaving groups failed.

SYNTHETIC METHODS FOR SPIRO-OXINDOLE COMPOUNDS

This invention is directed to methods of preparing certain spiro-oxindole derivatives, which are useful for the treatment and/or prevention of sodium channel-mediated diseases or conditions, such as pain.