126-38-5Relevant academic research and scientific papers
Novel method for synthesizing 1-bromo-2,2-dimethoxypropane
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Page/Page column 4-6, (2020/07/15)
The invention belongs to the technical field of biomedical intermediates, and provides a novel method for synthesizing 1-bromo-2,2-dimethoxypropane, wherein the method comprises the following steps: S1, bromination reaction: dissolving acetone in dichloromethane, preheating to 65 DEG C, adding bromine, controlling the temperature at 65-75 DEG C, and carrying out a reaction for 11-13 h to obtain 1-bromoacetone; S2, carrying out an up-protection reaction: dissolving 1-bromoacetone in methanol, adding trimethyl orthoformate and concentrated hydrochloric acid, and carrying out a reaction for 2-3 hto obtain 1-bromo-2,2-dimethoxypropane. By means of the technical scheme, the problems that in the prior art, hazardous materials are used in a method for synthesizing 1-bromo-2,2-dimethoxypropane, the yield is low, and a product is difficult to purify are solved.
Scavenger assisted combinatorial process for preparing libraries of tertiary amine compounds
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, (2008/06/13)
This invention relates to a novel solution phase process for the preparation of tertiary amine combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.
