1260023-91-3

Upstream product

• 1258440-86-6 5-(5-bromo-1,3-thiazol-2-yl)-2-[(1-methylethyl)oxy]benzonitrile 
• 1260023-43-5 2-ethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde 
• 1344998-38-4 (3-bromo-2-ethylphenyl)(hydroxy)methanesulfonic acid 
• 1258440-77-5 3-bromo-2-ethylbenzaldehyde 
• 1258440-85-5 2-[(1-methylethyl)oxy]-5-(1,3-thiazol-2-yl)benzonitrile 
• 1258440-84-4 2-[(1-methylethyl)oxy]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 41053-30-9 1,3-dibromo-2-ethyl-benzene 
• 515832-52-7 5-bromo-2-[(1-methylethyl)oxy]benzonitrile 
• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 108-36-1 1,3-dibromobenzene 

Downstream Products

• 1260024-06-3 methyl N-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]methyl}-N-methylglycinate 
• 1344997-74-5 ethyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]methyl}-4-piperidinecarboxylate 
• 1344997-99-4 ethyl (2E)-3-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]-2-propenoate 
• 1344997-77-8 methyl 1-{[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]methyl}-3-azetidinecarboxylate 
• 1344998-00-0 ethyl 3-[3-(2-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,3-thiazol-5-yl)-2-ethylphenyl]propanoate 
• 1344998-01-1 5-{5-[2-ethyl-3-(3-oxopropyl)phenyl]-1,3-thiazol-2-yl}-2-[(1-methylethyl)oxy]benzonitrile 

Relevant academic research and scientific papers

COMPOUNDS AS AGONISTS OF S1P1 RECEPTORS

Compounds of formula (I), processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by S1P1 receptors.

5-MEMBERED HETEROARYL DERIVATIVES USED AS SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS

5-membered heteroaryl derivatives of formula (I) or salts thereof, processes for their preparation, pharmaceutical compositions containing them and their uses in the treatment of various disorders mediated by S1P1 receptors are disclosed.