1260067-80-8

Basic information

• Product Name: C₁₉H₂₀N₅O₁₀P
• Synonyms: C₁₉H₂₀N₅O₁₀P
• CAS NO: 1260067-80-8
• Molecular Weight: 509.369
• Mol File: 1260067-80-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₉H₂₀N₅O₁₀P(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₂₀N₅O₁₀P(1260067-80-8)
• EPA Substance Registry System: C₁₉H₂₀N₅O₁₀P(1260067-80-8)

Safety Data

• Hazardous Substances Data: 1260067-80-8(Hazardous Substances Data)

Upstream product

• 58-61-7 adenosine 
• 1259874-82-2 C₄₃H₃₈N₅O₁₃P 
• 69530-93-4 5'-(O-tert-butyldimethylsilyl)adenosine 
• 58463-04-0 N6,N6,2'-O,3'-O-tetrabenzoyladenosine 
• 1031809-76-3 O^5'-tert-butyldimethylsilyl-N⁶,N⁶,O^2',O^3'-tetrabenzoyladenosine 

Relevant articles and documents

Design and synthesis of α-carboxy phosphononucleosides

Rhodium catalyzed O-H insertion reactions employing α- diazophosphonate 20 with appropriately protected thymidine, uridine, cytosine, adenosine and guanosine derivatives leads to novel 5′-phosphononucleoside derivatives. Deprotection led to a novel series of phosphono derivatives bearing a carboxylic acid moiety adjacent to the phosphonate group with potential antiviral and/or anticancer activity. The phosphononucleosides bearing an α-carboxylic acid group are envisaged as potential diphosphate mimics. Conversion to mono- and diphosphorylated phosphononucleosides has been effected for evaluation as nucleoside triphosphate mimics. Most of the novel phosphononucleosides proved to be inactive against a variety of DNA and RNA viruses. Only the phosphono AZT derivatives 56-59 showed weak activity against HIV-1 and HIV-2.