1260072-94-3Relevant academic research and scientific papers
Practical synthesis of (2′ R)-2′-deoxy-2′-C-methyluridine by highly diastereoselective homogeneous hydrogenation
Lemaire, Sebastien,Houpis, Ioannis,Wechselberger, Rainer,Langens, Jaak,Vermeulen, Wim A. A.,Smets, Nico,Nettekoven, Ulrike,Wang, Youchu,Xiao, Tingting,Qu, Haisheng,Liu, Renmao,Jonckers, Tim H.M.,Raboisson, Pierre,Vandyck, Koen,Nilsson, Karl M.,Farina, Vittorio
, p. 297 - 300 (2011)
Diastereoselective hydrogenation of 2′-deoxy-2′-exo- methyleneuridine was carried out under homogeneous conditions using a low loading of a chiral Rh catalyst. This, coupled with improvements in the synthesis of the substrate, allowed the smooth pilot plant preparation of the title compound on >10 kg scale.
