Practical synthesis of (2′ R)-2′-deoxy-2′-C-methyluridine by highly diastereoselective homogeneous hydrogenation

Article abstract of DOI:10.1021/jo101822j

Diastereoselective hydrogenation of 2′-deoxy-2′-exo- methyleneuridine was carried out under homogeneous conditions using a low loading of a chiral Rh catalyst. This, coupled with improvements in the synthesis of the substrate, allowed the smooth pilot plant preparation of the title compound on >10 kg scale.