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PKR-IN-1 is a potent and selective inhibitor of the protein kinase double-stranded RNA-dependent protein kinase (PKR), which is an important regulator of cellular stress response and plays a critical role in the innate immune system. By inhibiting PKR, PKR-IN-1 can potentially modulate various cellular pathways and processes involved in inflammation, apoptosis, and autophagy.

1260075-17-9

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1260075-17-9 Usage

Uses

Used in Neurodegenerative Disease Treatment:
PKR-IN-1 is used as a neuroprotective agent for its potential to treat conditions such as neurodegenerative diseases. Its anti-inflammatory and neuroprotective effects have been demonstrated in preclinical studies, suggesting its therapeutic potential in this area.
Used in Viral Infection Treatment:
PKR-IN-1 is used as an antiviral agent due to its ability to modulate the innate immune system, which may help in the treatment of viral infections.
Used in Cancer Therapy:
PKR-IN-1 is used as a therapeutic agent for cancer treatment, as its modulation of cellular pathways involved in inflammation and apoptosis may contribute to the management of cancerous conditions.
Further research and clinical studies are needed to fully understand the potential applications and mechanisms of action of PKR-IN-1 in these areas.

Check Digit Verification of cas no

The CAS Registry Mumber 1260075-17-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,0,7 and 5 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1260075-17:
(9*1)+(8*2)+(7*6)+(6*0)+(5*0)+(4*7)+(3*5)+(2*1)+(1*7)=119
119 % 10 = 9
So 1260075-17-9 is a valid CAS Registry Number.

1260075-17-9Downstream Products

1260075-17-9Relevant academic research and scientific papers

CRYSTALLINE FORMS OF N-(4-(4-(CYCLOPROPYLMETHYL) PIPERAZINE-1-CARBONYL)PHENYL)QUINOLINE-8-SULFONAMIDE

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, (2019/06/11)

Provided herein are amorphous and crystalline hemisulfate salt forms of the formula (I). Also provided are pharmaceutical compositions comprising the amorphous and crystalline hemisulfate salt forms, methods for their manufacture, and uses thereof for tre

THERAPEUTIC COMPOUNDS AND COMPOSITIONS

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Page/Page column 90-91, (2011/01/05)

Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.

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