1260098-82-5

Basic information

• Product Name: 4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazine-1-carboxylic acid ethyl ester
• CAS NO: 1260098-82-5
• Molecular Weight: 417.549
• Mol File: 1260098-82-5.mol

Chemical Properties

• CAS DataBase Reference: 4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazine-1-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazine-1-carboxylic acid ethyl ester(1260098-82-5)
• EPA Substance Registry System: 4-(2-{4-[3-((R)-2-methyl-pyrrolidin-1-yl)-propoxy]-phenyl}-2-oxo-ethyl)-piperazine-1-carboxylic acid ethyl ester(1260098-82-5)

Safety Data

• Hazardous Substances Data: 1260098-82-5(Hazardous Substances Data)

Upstream product

• 219509-82-7 tert-butyl 4-ethoxycarbonylpiperazine-1-carboxylate 
• 99-93-4 4-Hydroxyacetophenone 
• 91427-23-5 1-[4-(3-chloropropoxy)phenyl]ethanone 
• 1391636-61-5 C₁₈H₂₅ClN₂O₄ 
• 41720-98-3 (R)-2-methylpyrrolidine hydrochloride 
• 120-43-4 4-ethoxycarbonylpiperazine 
• 114604-68-1 α-bromo-4-(3-chloropropoxy)acetophenone 

Relevant articles and documents

Substituted phenoxypropyl-(R)-2-methylpyrrolidine aminomethyl ketones as histamine-3 receptor inverse agonists

Optimization of a series of aminomethyl ketone diamine H3R antagonists to reduce the brain exposure by lowering the pKa, led to molecules with improved pharmacokinetic properties. Compounds 9, 19, and 25 had high affinity for human H3R and demonstrated in vivo H3R functional activity in the rat dipsogenia model. Compound 9 displayed modest wake-promoting activity in the rat EEG/EMG model.

SUBSTITUTED PHENOXYPROPYLCYCLOAMINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS

The present invention provides compounds of formula I: their use as H3 antagonists/inverse agonists, processes for their preparation, and pharmaceutical compositions thereof.