1260143-64-3Relevant academic research and scientific papers
Br?nsted acid-catalyzed 1,2-fluorine migration with fluoroepoxides
Luo, Tao,Zhang, Rui,Shen, Xiao,Zhang, Wei,Ni, Chuanfa,Hu, Jinbo
supporting information, p. 19636 - 19641 (2015/11/27)
A catalytic 1,2-fluorine migration reaction with simple fluoroepoxides at room temperature is reported. Under Br?nsted acid catalysis, α-fluorinated ketones are efficiently constructed in the absence of an external fluorine source through a 1,2-fluorine migration reaction. The experimental results indicate that the present 1,2-fluorine migration reaction proceeds via a carbocation intermediate.
Efficient synthesis and ring-opening reactions of monofluorinated epoxides derived from α-fluorosulfoximines
Zhang, Wei,Hu, Jinbo
supporting information; experimental part, p. 2799 - 2804 (2010/12/25)
Monofluorinated epoxides were successfully prepared through the O-cyclization reaction between α-fluorosulfoximines and ketones. The obtained fluoroepoxides were found to readily undergo an interesting ring-opening process (involving both a C-F bond cleavage and another C-F bond formation) in the presence of titanium tetrafluoride or pyridinium poly(hydrogen fluoride) to afford α-fluorinated ketones. The later process constitutes a formal catalytic 1,2-fluorine shift reaction.
