1260159-06-5Relevant academic research and scientific papers
Synthesis, cytotoxicity, and structure-activity relationship (SAR) studies of andrographolide analogues as anti-cancer agent
Das, Bimolendu,Chowdhury, Chinmay,Kumar, Deepak,Sen, Rupashree,Roy, Rajneeta,Das, Padma,Chatterjee, Mitali
, p. 6947 - 6950 (2010)
A series of analogues of andrographolide, prepared through chemo-selective functionalization at C14 hydroxy, have been evaluated for in vitro cytotoxicities against human leukemic cell lines. Two of the analogues (6a, 9b) exhibited significant potency. Preliminary studies on structure-activity relationship (SAR) revealed that the α-alkylidene-γ-butyrolactone moiety of andrographolide played a major role in the activity profile. The structures of the analogues were established through spectroscopic and analytical data.
