1260167-19-8

Basic information

• Product Name: 2-methyl-2-(4-(8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
• Synonyms: 2-methyl-2-(4-(8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile
• CAS NO: 1260167-19-8
• Molecular Weight: 342.4
• Mol File: 1260167-19-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-methyl-2-(4-(8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-2-(4-(8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile(1260167-19-8)
• EPA Substance Registry System: 2-methyl-2-(4-(8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile(1260167-19-8)

Safety Data

• Hazardous Substances Data: 1260167-19-8(Hazardous Substances Data)

Upstream product

• 115279-57-7 2-(4-aminophenyl)-2-methylpropionitrile 
• 71825-51-9 4-(2-cyanoprop-2-yl)-1-nitrobenzene 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 1260167-14-3 2-(4-(3-amino-6-methyl-quinolin-4-ylamino)phenyl)-2-methyl propanenitrile 
• 256923-67-8 6-methyl-3-nitroquinolin-4-ol 
• 99010-06-7 4-chloro-6-methyl-3-nitroquinoline 
• 1260167-12-1 2-methyl-2-(4-(6-methyl-3-nitroquinolin-4-ylamino)phenyl) propanenitrile 
• 1260167-09-6 5-methyl-2-(2-nitrovinylamino)benzoic acid 

Downstream Products

• 1260167-97-2 (E)-2-(4-(3-but-2-enoyl-8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1260167-66-5 2-methyl-2-(4-(8-methyl-2-oxo-3-(quinolin-8-ylsulfonyl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1260167-64-3 2-(4-(3-(3-fluorophenylsulfonyl)-8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 
• 1260167-62-1 2-methyl-2-(4-(8-methyl-2-oxo-3-(m-tolylsulfonyl)-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1260168-07-7 2-methyl-2-(4-(8-methyl-3-(2-methyl-5-nitrophenylsulfonyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile 
• 1260167-68-7 2-(4-(3-(4-acetylphenylsulfonyl)-8-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile 

Relevant articles and documents

IMIDAZO [4,5-C]QUINOLINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF TUMORS AND/OR INFLAMMATION

The present invention provides the compounds of formula (I): The present invention relates to imidazo[4,5-c]quinoline derivatives of formula (I), process for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases mediated by phosphatidylinositol-3-kinase (PBK) and/or mammalian target of rapamycin (mTOR) and/or tumor necrosis factor-α (TNF-oc) and/or interleukin-6 (IL-6), particularly in the treatment of cancer and inflammation.