126017-85-4

Upstream product

• 65084-17-5 5-Hydroxy-1-((S)-1-phenyl-ethyl)-pyrrolidin-2-one 
• 762-72-1 allyl-trimethyl-silane 
• 134457-94-6 1-((S)-1-Phenyl-ethyl)-5-(toluene-4-sulfonyl)-pyrrolidin-2-one 
• 1730-25-2 allylmagnesium bromide 
• 24850-33-7 allyltributylstanane 
• 62993-44-6 1-[(1S)-1-phenylethyl]pyrrolidine-2,5-dione 
• 2627-86-3 (S)-1-phenyl-ethylamine 

Downstream Products

• 129784-74-3 (5S,9R)-5-methylindolizidine 
• 792183-69-8 (5R,9R)-5-methylindolizidine 
• 129708-97-0 (5R,9R)-(+)-5-cyanoindolizidine 
• 129708-94-7 (2S)-(-)-2-(4,4-dimethoxybutyl)-1-((1S)-1-phenylethyl)-pyrrolidine 
• 129708-94-7 (S)-2-(4,4-Dimethoxy-butyl)-1-(1-phenyl-ethyl)-pyrrolidine 
• 129708-90-3 (2S)-(-)-1-((1S)-1-phenylethyl)-2-(1-prop-2-enyl)-pyrrolidine 
• 126017-68-3 (5S)-(-)-1-<(1S)-1-Phenylethyl>-5-propyl-2-pyrrolidinone 
• 126017-66-1 (5R)-(-)-1-<(1S)-1-Phenylethyl>-5-propyl-2-pyrrolidinone 
• 82259-09-4 (5S)-(+)-5-(1-Prop-2-enyl)-2-pyrrolidinone 

Relevant academic research and scientific papers

N -Acyliminium Ion Chemistry: Improving the Access to Unsaturated γ-Lactams and Their N -α-Methoxylated Derivatives: Application to an Expeditive Synthesis of (±)-Crispine A

An improved synthesis of unsaturated γ-lactams by condensation of various primary amines with 2,5-dimethoxy-2,5-dihydrofuran is described. A modified mechanism for this reaction is suggested. Synthesis of their N -α-methoxylated derivatives, as N -acyliminium ion precursors, is also reported. Finally, a short synthesis of (±)-crispine A is presented as an illustrative application.

Asymmetric induction α to nitrogen in pyrrolidines and piperidines via radical chemistry

Attempts to control the stereochemistry of radical reactions at the 2-position of pyrrolidines and piperidines carrying chiral auxiliaries on the nitrogen are presented.

Enantioselective Total Synthesis of Indolizidine Alkaloids (-)-205A and (-)-235B

Enantioselective total syntheses of indolizidine alkaloids (-)-205A and (-)-235B are described.The syntheses proceed via a common late-stage intermediate, α-aminonitrile 1.Absolute stereochemical control over the C8 and C8a stereocenters in these material

Enantioselective Total Syntheses of Indolizidine Alkaloids 167B and 209D

Enantioselective total syntheses of the indolizidine alkaloids 167B and 209D are described.The sytheses proceed via a common late-stage intermediate, amino nitrile 8.Each alkaloid was prepared in 10 steps and approximately 23percent overall yield from (S)

Stereoselective Nucleophilic Additions to the Carbon-Nitrogen Double Bond. 3. Chiral Acyliminium Ions

(S)-(-)-α-Phenethylamine (3), (S)-(-)-1-(2-chlorophenyl)ethylamine (4), (S)-(-)-1-(2,6-dichlorophenyl)ethylamine (5), and (S)-(-)-1-(2,3,4,5,6-pentachlorophenyl)ethylamine (6) have been incorporated into acyliminium ions of structural type 1 and 2.Five-me