126017-91-2

Upstream product

• 62787-45-5 6-Hydroxy-1-((S)-1-phenyl-ethyl)-piperidin-2-one 
• 762-72-1 allyl-trimethyl-silane 
• 132363-91-8 (-)-6-ethoxy-1-((S)-1-phenylethyl)-2-piperidinone 
• 108-55-4 glutaric anhydride, 
• 126017-75-2 4-((S)-1-Phenyl-ethylcarbamoyl)-butyric acid 
• 126017-74-1 (S)-1-(1-phenylethyl)piperidine-2,6-dione 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 24850-33-7 allyltributylstanane 

Downstream Products

• 126017-67-2 (6R)-(-)-1-<(1S)-1-Phenylethyl>-5-propyl-2-piperidinone 
• 126017-69-4 (6S)-(-)-1-<(1S)-1-Phenylethyl>-5-propyl-2-piperidinone 
• 132363-94-1 (2S)-(-)-1-((1S)-1-phenylethyl)-2-(1-prop-2-enyl)piperidine 
• 132363-95-2 (2R)-(-)-1-((1S)-1-phenylethyl)-2-(1-prop-2-enyl)piperidine 
• 555-92-0 (S)-coniine hydrochloride 

Relevant academic research and scientific papers

Synthesis and Structure-Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues

The lactone derivative of the epoxyisoprostane EC is a highly effective inhibitor of the secretion of the proinflammatory cytokine IL-6. Herein, a modular synthesis of analogues is described, allowing flexible variations of the cyclic side chain of the parent lactone. A structure-activity relationship study identified a lactam analogue that retains the high activity. Furthermore, the exocyclic allylic alcohol was shown to be crucial for the observed effect.

Asymmetric induction α to nitrogen in pyrrolidines and piperidines via radical chemistry

Attempts to control the stereochemistry of radical reactions at the 2-position of pyrrolidines and piperidines carrying chiral auxiliaries on the nitrogen are presented.

ASYMMETRIC SYNTHESIS OF (+)- AND (-)-CONIINES AND (-)-SEDAMINE BY DIASTEREOSELECTIVE ALKYLATION REACTION OF ETHOXYPIPERIDININE

Diastereoselective alkylation reaction of the chiral 6-ethoxypiperidinones (4) and (5) has been developed and successfully applied to the asymmetric synthesis of piperidine alkaloids, (+)- and (-)-coiines (11) and (12), (-)-sedamine (21), and (-)-allosedamine (22).

Stereoselective Nucleophilic Additions to the Carbon-Nitrogen Double Bond. 3. Chiral Acyliminium Ions

(S)-(-)-α-Phenethylamine (3), (S)-(-)-1-(2-chlorophenyl)ethylamine (4), (S)-(-)-1-(2,6-dichlorophenyl)ethylamine (5), and (S)-(-)-1-(2,3,4,5,6-pentachlorophenyl)ethylamine (6) have been incorporated into acyliminium ions of structural type 1 and 2.Five-me