62787-45-5Relevant academic research and scientific papers
Synthesis and Structure-Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues
Wolleb, Helene,Ogawa, Seiji,Schneider, Michael,Shemet, Andrej,Muri, Jonathan,Kopf, Manfred,Carreira, Erick M.
, p. 3014 - 3016 (2018/05/28)
The lactone derivative of the epoxyisoprostane EC is a highly effective inhibitor of the secretion of the proinflammatory cytokine IL-6. Herein, a modular synthesis of analogues is described, allowing flexible variations of the cyclic side chain of the parent lactone. A structure-activity relationship study identified a lactam analogue that retains the high activity. Furthermore, the exocyclic allylic alcohol was shown to be crucial for the observed effect.
Stereoselective Nucleophilic Additions to the Carbon-Nitrogen Double Bond. 3. Chiral Acyliminium Ions
Polniaszek, Richard P.,Belmont, Stephen E.,Alvarez, Ramon
, p. 215 - 223 (2007/10/02)
(S)-(-)-α-Phenethylamine (3), (S)-(-)-1-(2-chlorophenyl)ethylamine (4), (S)-(-)-1-(2,6-dichlorophenyl)ethylamine (5), and (S)-(-)-1-(2,3,4,5,6-pentachlorophenyl)ethylamine (6) have been incorporated into acyliminium ions of structural type 1 and 2.Five-me
