1260216-06-5

Basic information

• Product Name: (8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone
• Synonyms: (8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone
• CAS NO: 1260216-06-5
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.17904
• Mol File: 1260216-06-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone(CAS DataBase Reference)
• NIST Chemistry Reference: (8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone(1260216-06-5)
• EPA Substance Registry System: (8aR)-2,3,8,8a-tetrahydro-7(1H)-Indolizinone(1260216-06-5)

Safety Data

• Hazardous Substances Data: 1260216-06-5(Hazardous Substances Data)

Upstream product

• 1240530-39-5 (S)-tert-butyl 2-(2-oxobut-3-yn-1-yl)pyrrolidine-1-carboxylate 
• 1202039-17-5 N-methoxy-N-methyl (R)-2-[N(1')-(tert-butoxycarbonyl)-pyrrolidin-2'-yl]ethanamide 
• 1260216-05-4 (R)-tert-butyl 2-(2-oxobut-3-yn-1-yl)pyrrolidine-1-carboxylate 
• 1315052-97-1 C₈H₁₁NO 
• 101555-60-6 2-(R)-carboxymethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 1260216-15-6 (R)-7-(2',3',4,5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 
• 1260216-17-8 (R)-7-(3',4,4',5-tetramethoxy-[1,1'-biphenyl]-2-yl)-1,2,3,5,8,8a-hexahydroindolizine 

Relevant articles and documents

Synthesis of tylocrebrine and related phenanthroindolizidines by VOF 3-mediated oxidative aryl-alkene coupling

A highly convergent strategy to prepare phenanthroindolizidines is reported involving three consecutive C-C coupling reactions. This sequence features a novel VOF3-mediated aryl-alkene coupling in the final step, which enables regioselective preparation of C5-substituted phenanthroindolizidines for the first time. This strategy has been applied to the synthesis of eight natural and unnatural members in this class to investigate the scope of this chemistry and to explore structure-activity relationships.