1260235-46-8

Basic information

• Product Name: 3-(1-(3,4-dichlorophenyl)-2-nitroethyl)-1H-indole
• Synonyms: 3-(1-(3,4-dichlorophenyl)-2-nitroethyl)-1H-indole
• CAS NO: 1260235-46-8
• Molecular Weight: 335.189
• Mol File: 1260235-46-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-(1-(3,4-dichlorophenyl)-2-nitroethyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(1-(3,4-dichlorophenyl)-2-nitroethyl)-1H-indole(1260235-46-8)
• EPA Substance Registry System: 3-(1-(3,4-dichlorophenyl)-2-nitroethyl)-1H-indole(1260235-46-8)

Safety Data

• Hazardous Substances Data: 1260235-46-8(Hazardous Substances Data)

Upstream product

• 120-72-9 indole 
• 37630-23-2 1,2-dichloro-4-(2-nitrovinyl)benzene 
• 37630-23-2 (E)-1,2-dichloro-4-(2-nitrovinyl)benzene 

Relevant articles and documents

Baker's yeast as an efficient biocatalyst for regioselective 1,4-conjugate addition of indoles to nitroolefins in aqueous medium

The 1,4-conjugate addition of indoles to nitroolefins was efficiently carried out in aqueous media using baker's yeast as a biocatalyst at room temperature. The merits of the present method are operational simplicity, easy workup, utilization of an inexpensive catalyst, free from hazardous organic solvents and good yields of products. The generality of this method was demonstrated by synthesizing an array of diverse 3-substituted indole derivatives and could be extended for dialkylation of 1,4-bis-(2-nitrovinyl)benzene.

Michael addition of indoles to β-nitrostyrenes catalyzed by HY zeolite under solvent-free conditions

Michael addition of indoles to β-nitrostyrenes is reported using HY zeolite as catalyst under mild reaction conditions. This methodology allows the synthesis of various indole derivatives in good to high yields at 50 C under solvent-free conditions. The short reaction time and achieving high yield of the desired products are the main advantages of the present work. The catalyst can be easily recovered and reused for six successive runs without considerable changes in yields. This Michael addition catalyzed by HY zeolite is operationally simple and can be considered as a greener protocol as it avoids the use of corrosive acids and toxic reagents.