1260247-51-5

Basic information

• Product Name: 2,5-dioxopyrrolidin-1-yl 3-{[2-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)ethyl]disulfanyl}propanoate
• Synonyms: 2,5-dioxopyrrolidin-1-yl 3-{[2-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)ethyl]disulfanyl}propanoate
• CAS NO: 1260247-51-5
• Molecular Weight: 751.944
• Mol File: 1260247-51-5.mol
• Article Data: 0

Chemical Properties

• Density: 1.36±0.1 g/cm3(Predicted)
• CAS DataBase Reference: 2,5-dioxopyrrolidin-1-yl 3-{[2-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)ethyl]disulfanyl}propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-dioxopyrrolidin-1-yl 3-{[2-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)ethyl]disulfanyl}propanoate(1260247-51-5)
• EPA Substance Registry System: 2,5-dioxopyrrolidin-1-yl 3-{[2-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)ethyl]disulfanyl}propanoate(1260247-51-5)

Safety Data

• Hazardous Substances Data: 1260247-51-5(Hazardous Substances Data)

Usage

Description

2,5-dioxopyrrolidin-1-yl 3-[2-(1-5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido-3,6,9,12-tetraoxapentadecan-15-amido)ethyl]disulfanylpropanoate is a complex organic compound featuring a pyrrolidine-2,5-dione core, a thienoimidazolidine ring, and a disulfide-containing linker. This molecule is designed to be a cleavable reagent, allowing for the introduction of specific functional groups to proteins and cell surfaces through the formation of disulfide bonds.

Uses

Used in Bioconjugation Applications:
2,5-dioxopyrrolidin-1-yl 3-[2-(1-5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido-3,6,9,12-tetraoxapentadecan-15-amido)ethyl]disulfanylpropanoate is used as a bioconjugation reagent for attaching biotin moieties to proteins and cell surfaces containing primary amines. The disulfide bond in the linker can be selectively cleaved using reducing agents such as DTT, BME, and TCEP, enabling the removal of the biotin label when needed.
Used in Drug Delivery Systems:
In the pharmaceutical industry, this compound can be utilized in the development of drug delivery systems that require specific targeting and release mechanisms. The disulfide bond's cleavability allows for controlled release of therapeutic agents in response to specific stimuli, such as the presence of reducing agents in the biological environment.
Used in Analytical Chemistry:
2,5-dioxopyrrolidin-1-yl 3-[2-(1-5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido-3,6,9,12-tetraoxapentadecan-15-amido)ethyl]disulfanylpropanoate can be employed in analytical chemistry for the development of assays and sensors that rely on the selective cleavage of disulfide bonds for signal transduction or detection purposes.

Downstream Products

• 1609243-43-7 tert-butyl 5-(3-{[2-(1-{5-[(3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazolidin-4-yl]pentanamido}-3,6,9,12-tetraoxapentadecan-15-amido)ethyl]disulfanyl}propanamido)-2-(methylamino)benzoate 
• 1340586-71-1 BP₄SSAC 
• 1260247-54-8 N-(2-((3-(propargylamino)-3-oxopropyl)disulfanyl)ethyl)-1-(5-((3aS,4S,6aR)-2-oxo-hexahydro-1H-thieno[3,4-d]imidazol-4-yl)-pentanamido)-3,6,9,12-tetraoxapentadecan-15-amide