1260376-38-2

Upstream product

• 73414-58-1 2-(3,5-dibromo-4-hydroxyphenyl)ethan-1-amine hydrobromide 
• 814-68-6 acryloyl chloride 

Downstream Products

• 1260376-34-8 (E)-N-(3-bromo-4-hydroxyphenethyl)-3-(3-bromo-4-methoxyphenyl)acrylamide 
• 1110659-40-9 (E)-3-(3-bromo-4-methoxyphenyl)-N-(3,5-dibromo-4-hydroxyphenethyl)acrylamide 

Relevant academic research and scientific papers

The development of a general strategy for the synthesis of tyramine-based natural products by using continuous flow techniques

A flowing future! A multistep, general flow chemistry protocol has been developed for the preparation of tyramine-based natural products. The process integrates room-temperature reactions with high-temperature Heck coupling reactions, where the heat has been supplied by microwave irradiation. As a proof of concept for 'scaling out' to attain larger quantities of the desired products, the four primary tyramine-based natural products were prepared on a gram scale using this synthetic protocol.