1260381-83-6

Basic information

• Product Name: 1H-Indazole,5-broMo-7-fluoro-
• Synonyms: 1H-Indazole,5-broMo-7-fluoro-;5-BroMo-7-fluoro-1H-indazole;5-bromo-7-fluoro-1H-indzole
• CAS NO: 1260381-83-6
• Molecular Formula: C₇H₄BrFN₂
• Molecular Weight: 215.0224632
• Mol File: 1260381-83-6.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 331.3±22.0 °C(Predicted)
• Appearance: /
• Density: 1.861±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.84±0.40(Predicted)
• CAS DataBase Reference: 1H-Indazole,5-broMo-7-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indazole,5-broMo-7-fluoro-(1260381-83-6)
• EPA Substance Registry System: 1H-Indazole,5-broMo-7-fluoro-(1260381-83-6)

Safety Data

• Hazardous Substances Data: 1260381-83-6(Hazardous Substances Data)

Usage

Potential pharmacological properties

anti-cancer, anti-inflammatory, and antimicrobial agents
Presence of bromine and fluorine atoms may impart specific chemical and biological properties
Potentially useful in the development of new pharmaceuticals or other applications in medicinal chemistry
Requires further research and investigation to fully understand its potential uses and effects.

Upstream product

• 1365889-33-3 (E)-5-bromo-2,3-difluorobenzaldehyde O-methyl oxime 
• 633327-22-7 5-bromo-2,3-difluorobenzaldehyde 
• 2646-91-5 2,3-difluorobenzaldehyde 

Downstream Products

• 633327-24-9 7-fluoro-1H-indazole-5-carbonitrile 

Relevant articles and documents

Compounds and their use in treatment on hepatitis B

The invention provides compounds, a pharmaceutical composition containing the compounds and an application of the compounds. The compound is a compound shown in a formula (I) or a stereoisomer, a tautomer, nitric oxide, hydrate, solvate, metabolite, pharmaceutically acceptable salt or prodrug of the compound shown in the formula (I). The compound provided by the invention can interfere with the shell assembly process of hepatitis B virus, thereby inhibiting hepatitis B virus replication. Moreover, the compound has good absorption, relatively high biological activity and availability and low toxicity, particularly has relatively strong stability in vivo, is not easy to decompose and has long drug effect time, so that an effect of treating hepatitis B is achieved and the compound has a goodapplication prospect.

Amino pyrimidine compound and preparation method and application thereof

The invention relates to an amino pyrimidine compound and a preparation method and application thereof. The amino pyrimidine compound has a structure as shown in a formula I. The formula is shown in the description. The compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The invention further relates to a medicine composition comprising the compound, a preparation methodand application thereof in preparation of anti-tumor medicines.

3-(1H-PYRROLO[2,3-C]PYRIDIN-2-YL)-1H-INDAZOLES AND THERAPEUTIC USES THEREOF

Indazole compounds for treating various diseases and pathologies are disclosed. More particularly, the present disclosure concerns the use of an indazole compound or analogs thereof, in the treatment of disorders characterized by the activation of Wnt pathway signaling (e.g., cancer, abnormal cellular proliferation, angiogenesis, fibrotic disorders, bone or cartilage diseases, and osteoarthritis), the modulation of cellular events mediated by Wnt pathway signaling, as well as genetic diseases and neurological conditions/disorders/diseases due to mutations or dysregulation of the Wnt pathway and/or of one or more of Wnt signaling components. Also provided are methods for treating Wnt-related disease states.