1260403-59-5

Basic information

• Product Name: Methyl 1-(2-(3,5-difluorophenyl)-2-hydroxyethylaMino)cyclopentanecarboxylate
• Synonyms: 1-[[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethyl]amino]cyclopentanecarboxylic acid methyl ester;Cyclopentanecarboxylic acid, 1-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethyl]amino]-, methyl ester;Methyl 1-(2-(3,5-difluorophenyl)-2-hydroxyethylaMino)cyclopentanecarboxylate;methyl 1-((2-(3,5-difluorophenyl)-2-hydroxyethyl)amino)cyclopentane-1-carboxylate
• CAS NO: 1260403-59-5
• Molecular Formula: C₁₅H₁₉F₂NO₃
• Molecular Weight: 299.3130664
• Mol File: 1260403-59-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 411.0±45.0 °C(Predicted)
• Appearance: /
• Density: 1.25
• PKA: 13.36±0.20(Predicted)
• CAS DataBase Reference: Methyl 1-(2-(3,5-difluorophenyl)-2-hydroxyethylaMino)cyclopentanecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-(2-(3,5-difluorophenyl)-2-hydroxyethylaMino)cyclopentanecarboxylate(1260403-59-5)
• EPA Substance Registry System: Methyl 1-(2-(3,5-difluorophenyl)-2-hydroxyethylaMino)cyclopentanecarboxylate(1260403-59-5)

Safety Data

• Hazardous Substances Data: 1260403-59-5(Hazardous Substances Data)

Upstream product

• 1260403-60-8 CH₄O₃S*C₁₅H₁₉F₂NO₃ 
• 1260403-58-4 CH₄O₃S*C₁₅H₁₇F₂NO₃ 
• 60421-23-0 cycloleucine methyl ester hydrochloride 
• 220607-75-0 2-bromo-1-(3,5-difluorophenyl)ethanone 

Downstream Products

• 957121-89-0 ethyl [(8R)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate 
• 957118-49-9 [3H]-MK 3207 
• 957187-34-7 C₁₆H₁₈F₂N₂O₃ 

Relevant articles and documents

PROCESS FOR MAKING CGRP RECEPTOR ANTAGONIST

The invention encompasses a novel process for making 2-[(8R)-8-(3,5-Difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]-N-[(2R)-2'-oxo-1,1',2',3-tetrahydrospiro[indene-2,3'-pyrrolo[2,3-b]pyridin]-5-yl]acetamide, which is a CGRP receptor antagonist useful for the treatment of migraine, using an asymmetric phase-transfer catalysis route. The invention also encompasses an efficient and practical synthesis of the (R)-acid intermediate, and generates the benzylic stereocenter in an enantioselective manner.