60421-23-0

Basic information

• Product Name: Methyl 1-amino-1-cyclopentanecarboxylate hydrochloride
• Synonyms: METHYL 1-AMINOCYCLOPENTYLCARBOXYLATE HCL;methyl 1-aminocyclopentanecarboxylate, HCl;Cycloeucine methyl ester hydrochloride;Cyclopentanecarboxylic acid, 1-amino-, methyl ester, hydrochloride;Nsc161119;1-Amino-1-cyclopentanecarboxylic acid methyl ester hydrochloride;cycloeucinemethyl ester HCL;AC5C-OMe HCl
• CAS NO: 60421-23-0
• Molecular Formula: C₇H₁₃NO₂*ClH
• Molecular Weight: 179.64
• EINECS: 200-110-4
• Product Categories: Cycloalkanes
• Mol File: 60421-23-0.mol
• Article Data: 27

Chemical Properties

• Melting Point: 207-208 °C (decomp)
• Boiling Point: 186.7 °C at 760 mmHg
• Flash Point: 58.7 °C
• Appearance: /
• Density: 1.081g/cm³
• Vapor Pressure: 0.653mmHg at 25°C
• Refractive Index: 1.478
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: Methyl 1-amino-1-cyclopentanecarboxylate hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1-amino-1-cyclopentanecarboxylate hydrochloride(60421-23-0)
• EPA Substance Registry System: Methyl 1-amino-1-cyclopentanecarboxylate hydrochloride(60421-23-0)

Safety Data

• Hazardous Substances Data: 60421-23-0(Hazardous Substances Data)

Usage

General Description

Methyl 1-amino-1-cyclopentanecarboxylate hydrochloride is a chemical compound with the molecular formula C7H12ClNO2. It is a salt form of the organic compound methyl 1-amino-1-cyclopentanecarboxylate, which is commonly used in the synthesis of various pharmaceuticals and agrochemicals. The hydrochloride salt form increases the solubility and stability of the compound, making it more suitable for use in pharmaceutical formulations. Methyl 1-amino-1-cyclopentanecarboxylate hydrochloride is a versatile building block in organic synthesis and is commonly used in the production of active pharmaceutical ingredients. It is also used as a chiral auxiliary in asymmetric synthesis to control the stereochemistry of reactions.

InChI:InChI=1/C7H13NO2/c1-10-6(9)7(8)4-2-3-5-7/h2-5,8H2,1H3

Upstream product

• 75-36-5 acetyl chloride 
• 52-52-8 1-amino-1-cyclopentanecarboxylic acid 
• 120-92-3 cyclopentanone 
• 699-51-4 1,3-diazaspiro[4.4]nonane-2,4-dione 
• 248262-96-6 methyl 1-((tert-butoxycarbonyl)amino)cyclopentanecarboxylate 
• 1001426-16-9 [1-(1-hydroxy-1-methylethyl)cyclopentyl]carbamic acid tert-butyl ester 
• 67-56-1 methanol 

Downstream Products

• 139456-12-5 7-Acetyl-9-(4-chloro-phenyl)-6,8,9-triaza-spiro[4.5]dec-7-en-10-one 
• 10316-79-7 (1-aminocyclopentyl)methanol 
• 819055-38-4 1-{[5-(biphenyl-4-yloxymethyl)-furan-2-carbonyl]-amino}-cyclopentane carboxylic acid methyl ester 
• 863639-59-2 methyl 1-({[5-[4-(benzyloxy)phenyl]-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl]carbonyl}amino)cyclopentanecarboxylate 
• 957122-37-1 methyl 1-({(3S)-3-[(tert-butoxycarbonyl)amino]-3-phenylpropyl}amino)cyclopentanecarboxylate 
• 957121-88-9 methyl 1-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}cyclopentanecarboxylate 
• 957122-02-0 methyl 1-[(2-oxo-2-phenylethyl)amino]cyclopentanecarboxylate 
• 1263291-80-0 methyl 1-{[2-(3,5-difluorophenyl)-2-oxoethyl]amino}cyclopentanecarboxylate trifluoroacetate 
• 569654-43-9 1-[4-(toluene-4-sulfonyl)-piperazin-1-yl]-cyclopentanecarboxylic acid methyl ester 
• 138401-24-8 4'-[(2-butyl-4-oxo-1,3-diazaspiro[4.4]non-1-en-3-yl)methyl]-[1,1'-biphenyl]-2-carbonitrile 
• 840506-49-2 phenyl-(methoxy-α,α-cycloleucinyl)-phosphorochloridate 

Relevant articles and documents

Hydrogen-Borrowing Alkylation of 1,2-Amino Alcohols in the Synthesis of Enantioenriched γ-Aminobutyric Acids

For the first time we have been able to employ enantiopure 1,2-amino alcohols derived from abundant amino acids in C?C bond-forming hydrogen-borrowing alkylation reactions. These reactions are facilitated by the use of the aryl ketone Ph*COMe. Racemisation of the amine stereocentre during alkylation can be prevented by the use of sub-stoichiometric base and protection of the nitrogen with a sterically hindered triphenylmethane (trityl) or benzyl group. The Ph* and trityl groups are readily cleaved in one pot to give γ-aminobutyric acid (GABA) products as their HCl salts without further purification. Both steps may be performed in sequence without isolation of the hydrogen-borrowing intermediate, removing the need for column chromatography.

Distal Stereocontrol Using Guanidinylated Peptides as Multifunctional Ligands: Desymmetrization of Diarylmethanes via Ullman Cross-Coupling

We report the development of a new class of guanidine-containing peptides as multifunctional ligands for transition-metal catalysis and its application in the remote desymmetrization of diarylmethanes via copper-catalyzed Ullman cross-coupling. Through design of these peptides, high levels of enantioinduction and good isolated yields were achieved in the long-range asymmetric cross-coupling (up to 93:7 er and 76% yield) between aryl bromides and malonates. Our mechanistic studies suggest that distal stereocontrol is achieved through a Cs-bridged interaction between the Lewis-basic C-terminal carboxylate of the peptides with the distal arene of the substrate.

A COMPOUND FOR INHIBITING 11BETA-HYDROXY STEROID DEHYDROGENASE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Disclosed are a novel compound or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the same for inhibiting human 11-beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1). The disclosed compound and the pharmaceutical composition including the same for inhibiting human 11-beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) are excellent in activity and solubility, and is more efficient in formulation and transfer.