1260431-01-3

Basic information

• Product Name: N-methyl-N-(t-Boc)-PEG4-acid
• Synonyms: N-methyl-N-(t-Boc)-PEG4-acid;N-methyl-N-( Boc)-PEG4-acid;N-methyl-N-(t-Boc)-PEG4-COOH
• CAS NO: 1260431-01-3
• Molecular Formula: C17H33NO8
• Molecular Weight: 379.44582
• Mol File: 1260431-01-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-methyl-N-(t-Boc)-PEG4-acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-(t-Boc)-PEG4-acid(1260431-01-3)
• EPA Substance Registry System: N-methyl-N-(t-Boc)-PEG4-acid(1260431-01-3)

Safety Data

• Hazardous Substances Data: 1260431-01-3(Hazardous Substances Data)

Usage

Description

N-methyl-N-(t-Boc)-PEG4-acid is a PEG linker containing a t-Boc protecting group and a terminal carboxylic acid. The t-Boc protecting group is acid lablie. The terminal carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG linkers increase the water solubility of the compound in aqueous media.

Upstream product

• 74-88-4 methyl iodide 
• 756525-91-4 3-[2-[2-[2-[2-(tert-butoxycarbonylamino)ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid 

Relevant articles and documents

Conjudates of Pyrrolo[1,4]Benzodiazepine Dimers As Anticancer Agents

The present invention relates to pyrrolo[1,4]benzodiazepine (PBD) dimer conjugates, to the compositions comprising them and to their therapeutic application, in particular as anticancer agents. The invention also relates to the process for the preparation

NEW MAYTANSINOIDS AND THE USE OF SAID MAYTANSINOIDS TO PREPARE CONJUGATES WITH AN ANTIBODY

The invention relates to a compound of formula (I): wherein : ? ALK is a (C1-C6)alkylene group; ? X1 et X2 are each independently one of the following groups : -CH=CH-, -CO-, -CONR-, - NRCO-. -COO-. -OCO-. -OCONR-. -NRCOO-. -NRCONR'-. -NR-. -S(O)n (n=0,1 or 2) or O-; ? R and R' are independently H or a (C1-C6)alkyl group; ? I is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10; ? j is an integer corresponding to 1 when X2 is -CH=CH- and 2 when X2 is not -CH=CH-; ? Zb is a simple bond, -O- or -NH- and Rb is H or a (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl group; or Zb is a single bond and Rb is Hal. The invention relates to the use of said maytansinoids to prepare conjugates with an antibody having an affinity for tumor cells.