1260431-01-3 Usage
Uses
Used in Pharmaceutical and Bioconjugation Applications:
N-methyl-N-(t-Boc)-PEG4-acid serves as a PEG linker for the synthesis of bioconjugates and drug delivery systems. Its acid-labile t-Boc protecting group allows for selective deprotection under acidic conditions, which is crucial for controlled release or activation of the conjugated molecule. The terminal carboxylic acid enables the formation of stable amide bonds with primary amines, facilitating the attachment of various functional groups or therapeutic agents.
Used in Drug Delivery Systems:
In the drug delivery industry, N-methyl-N-(t-Boc)-PEG4-acid is utilized as a component in the design of targeted drug delivery systems. The PEG linkers improve the solubility and stability of the drug conjugates, while the acid-labile t-Boc group ensures that the drug can be released in a controlled manner, particularly in the acidic environments of tumor tissues or intracellular compartments.
Used in Polymer Science and Materials:
N-methyl-N-(t-Boc)-PEG4-acid is employed as a building block in the synthesis of functional polymers and materials. The PEG linkers contribute to the hydrophilicity and biocompatibility of the resulting materials, making them suitable for applications in coatings, hydrogels, and other biomaterials with specific requirements for water solubility and biological interaction.
Check Digit Verification of cas no
The CAS Registry Mumber 1260431-01-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,2,6,0,4,3 and 1 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1260431-01:
(9*1)+(8*2)+(7*6)+(6*0)+(5*4)+(4*3)+(3*1)+(2*0)+(1*1)=103
103 % 10 = 3
So 1260431-01-3 is a valid CAS Registry Number.
1260431-01-3Relevant academic research and scientific papers
NOVEL CONJUGATES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF
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, (2012/09/11)
Provided herein are cryptophycin conjugates and compositions containing them. Methods of making and using such compounds also are provided
Conjudates of Pyrrolo[1,4]Benzodiazepine Dimers As Anticancer Agents
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Page/Page column 45, (2012/10/08)
The present invention relates to pyrrolo[1,4]benzodiazepine (PBD) dimer conjugates, to the compositions comprising them and to their therapeutic application, in particular as anticancer agents. The invention also relates to the process for the preparation
NEW MAYTANSINOIDS AND THE USE OF SAID MAYTANSINOIDS TO PREPARE CONJUGATES WITH AN ANTIBODY
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Page/Page column 32-33, (2011/04/25)
The invention relates to a compound of formula (I): wherein : ? ALK is a (C1-C6)alkylene group; ? X1 et X2 are each independently one of the following groups : -CH=CH-, -CO-, -CONR-, - NRCO-. -COO-. -OCO-. -OCONR-. -NRCOO-. -NRCONR'-. -NR-. -S(O)n (n=0,1 or 2) or O-; ? R and R' are independently H or a (C1-C6)alkyl group; ? I is an integer of from 1 to 40, preferably from 1 to 20, and more preferably from 1 to 10; ? j is an integer corresponding to 1 when X2 is -CH=CH- and 2 when X2 is not -CH=CH-; ? Zb is a simple bond, -O- or -NH- and Rb is H or a (C1-C6)alkyl, (C3-C7)cycloalkyl, aryl, heteroaryl or (C3-C7)heterocycloalkyl group; or Zb is a single bond and Rb is Hal. The invention relates to the use of said maytansinoids to prepare conjugates with an antibody having an affinity for tumor cells.
