1260494-81-2Relevant academic research and scientific papers
Method for preparing substituted aryl methanol compounds through ruthenium catalysis
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Paragraph 0036; 0064; 0065; 0066; 0067; 0068, (2017/07/20)
The invention discloses a method for preparing substituted aryl methanol compounds through ruthenium catalysis. The method comprises the following step: under a nitrogen protection condition, with [Ru(p-cymene)Cl2]2 as a catalyst, Lewis acid as an additive and sodium acetate as alkali, performing a reaction on guiding group-containing aryl compounds adopting structures shown as a formula (I-1), (I-2), (I-3), (I-4), (I-5) or (I-6) and aldehydes shown as a formula (II) in an organic solvent at 40-80 DEG C to obtain the substituted aryl methanol compounds shown as a formula (III-1), (III-2), (III-3), (III-4), (III-5) or (III-6), wherein the Lewis acid is one of zinc chloride, zinc bromide, aluminum trichloride and aluminum tribromide. The method has the advantages of regional selectivity, a wide application range of a substrate, fast reaction, mild conditions, convenient operation, low cost and safe reaction.
Ru-Catalyzed Regioselective Direct Hydroxymethylation of (Hetero)Arenes via C-H Activation
Zhang, Guo-Fu,Li, Yue,Xie, Xiao-Qiang,Ding, Cheng-Rong
, p. 1216 - 1219 (2017/03/14)
An efficient and direct ruthenium-catalyzed regioselective hydroxymethylation of (hetero)arenes via C-H activation with paraformaldehyde as a hydroxymethylating reagent is described. The corresponding products can be obtained in good to excellent yield. A number of aryl aldehydes can also be used in place of paraformaldehyde giving the desired alcohol products with similarly good results.
