1260507-03-6Relevant articles and documents
Bronsted acid catalyzed C-H functionalization of N-protected tetrahydroisoquinolines via intermediate peroxides
Schweitzer-Chaput, Bertrand,Klussmann, Martin
supporting information, p. 666 - 671 (2013/03/13)
An organocatalytic oxidative synthesis of N-protected tetrahydroisoquinolines is described by C-H functionalization via intermediate peroxides. The peroxides were synthesized from tert-butylhydroperoxide under metal-free thermal conditions and were converted into the final products by Bronsted acid catalyzed substitution. The nucleophile scope was investigated in detail and proved to be broad; N-deprotection of the coupling products could also be achieved. An organocatalytic oxidative synthesis of N-protected tetrahydroisoquinolines was achieved by C-H functionalization via Intermediate PeroxideS (CHIPS). The peroxides were synthesized under metal-free thermal conditions and were converted into the final products by reaction with a variety of nucleophiles by using Bronsted acid catalysis. Copyright
Facile, solvent and ligand free iron catalyzed direct functionalization of N-protected tetrahydroisoquinolines and isochroman
Ghobrial, Michael,Harhammer, Karin,Mihovilovic, Marko D.,Schnuerch, Michael
supporting information; experimental part, p. 8836 - 8838 (2011/02/21)
An efficient method for an iron catalyzed oxidative indolation and methoxyphenylation of N-protected tetrahydroisoquinolines and isochroman is described including subsequent facile deprotection. The Royal Society of Chemistry 2010.