126062-22-4

Usage

InChI:InChI=1/C11H9BrClNO3/c12-3-4-16-11-9(13)7-2-1-6(14)5-8(7)10(15)17-11/h1-2,5H,3-4,14H2

Upstream product

• 141468-58-8 2-(2-bromo-ethoxycarbonylmethyl)-5-nitro-benzoic acid 
• 3898-66-6 2-(carboxymethyl)-5-nitrobenzoic acid 
• 89-51-0 Homophthalic acid 
• 141468-73-7 4-chloro-3-(2-bromo-ethoxy)-7-nitro-isocoumarin 

Downstream Products

• 131068-62-7 1-[3-(2-Bromo-ethoxy)-4-chloro-1-oxo-1H-isochromen-7-yl]-3-phenyl-urea 
• 141468-76-0 {(S)-1-[3-(2-Bromo-ethoxy)-4-chloro-1-oxo-1H-isochromen-7-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 141468-60-2 7-(N-t-butyloxycarbonyl-D-phenylalanyl)amino-4-chloro-3-(2-bromoethoxy)isocoumarin 

Relevant academic research and scientific papers

Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases

Activity-based probes (ABPs) have found increasing use in functional proteomics studies. Recently, ABPs that can be employed in combination with click chemistry gained particular attention due to their flexible application in vitro and in vivo. Moreover,

Isocoumarin-based inhibitors of urokinase-type plasminogen activator

The present invention relates to chemical compounds, pharmaceutical compositions and methods for treating tumors and cancer and diseases which involve angiogenesis including retinopathy, age-related macular degeneration, angiogenic skin disorders and infl

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease

A series of new 7-substituted-4-chloro-3-alkoxy isocoumarin derivatives were synthesized and evaluated as inhibitors of representative classes of proteases: serine protease (α-chymotrypsin, trypsin), cysteine protease (Caspase-3), and aspartyl protease (H

Mechanism-based isocoumarin inhibitors for blood coagulation serine proteases. Effect of the 7-substituent in 7-amino-4-chloro-3- (isothioureidoalkoxy)isocoumarins on inhibitory and anticoagulant potency

A series of 7-amino-4-chloro-3-(3-isothioureidopropoxy)isocoumarin (NH2- CiTPrOIC) derivatives with various substituents at the 7- and 3-positions have been synthesized as inhibitors of several blood coagulation enzymes. Isocoumarins substitute

SUBSTITUTED ISOCOUMARINS

Substituted isocoumarins, their use in inhibiting serine proteases with chymotrypsin-like and elastase-like specificity and their roles as anti-inflammatory agents.