126062-22-4

Basic information

• Product Name: 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin
• Synonyms: 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin
• CAS NO: 126062-22-4
• Molecular Formula: C₁₁H₉BrClNO₃
• Molecular Weight: 318.5511
• Mol File: 126062-22-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 509.9°Cat760mmHg
• Flash Point: 262.2°C
• Appearance: /
• Density: 1.73g/cm³
• Vapor Pressure: 1.62E-10mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin(126062-22-4)
• EPA Substance Registry System: 7-amino-3-(2-bromoethoxy)-4-chloroisocoumarin(126062-22-4)

Safety Data

• Hazardous Substances Data: 126062-22-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H9BrClNO3/c12-3-4-16-11-9(13)7-2-1-6(14)5-8(7)10(15)17-11/h1-2,5H,3-4,14H2

Upstream product

• 141468-58-8 2-(2-bromo-ethoxycarbonylmethyl)-5-nitro-benzoic acid 
• 3898-66-6 2-(carboxymethyl)-5-nitrobenzoic acid 
• 89-51-0 Homophthalic acid 
• 141468-73-7 4-chloro-3-(2-bromo-ethoxy)-7-nitro-isocoumarin 

Downstream Products

• 141468-60-2 7-(N-t-butyloxycarbonyl-D-phenylalanyl)amino-4-chloro-3-(2-bromoethoxy)isocoumarin 
• 141468-76-0 {(S)-1-[3-(2-Bromo-ethoxy)-4-chloro-1-oxo-1H-isochromen-7-ylcarbamoyl]-2-phenyl-ethyl}-carbamic acid tert-butyl ester 
• 131068-62-7 1-[3-(2-Bromo-ethoxy)-4-chloro-1-oxo-1H-isochromen-7-yl]-3-phenyl-urea 

Relevant articles and documents

Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases

Activity-based probes (ABPs) have found increasing use in functional proteomics studies. Recently, ABPs that can be employed in combination with click chemistry gained particular attention due to their flexible application in vitro and in vivo. Moreover,

Synthesis of new 3-alkoxy-7-amino-4-chloro-isocoumarin derivatives as new β-amyloid peptide production inhibitors and their activities on various classes of protease

A series of new 7-substituted-4-chloro-3-alkoxy isocoumarin derivatives were synthesized and evaluated as inhibitors of representative classes of proteases: serine protease (α-chymotrypsin, trypsin), cysteine protease (Caspase-3), and aspartyl protease (H

SUBSTITUTED ISOCOUMARINS

Substituted isocoumarins, their use in inhibiting serine proteases with chymotrypsin-like and elastase-like specificity and their roles as anti-inflammatory agents.