126062-63-3Relevant academic research and scientific papers
A class of GPR40 agonist compounds with amide structure, and uses thereof
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Paragraph 0115; 0116; 0118; 0121, (2019/05/02)
The present invention relates to a class of amide compounds with a novel structure, and a pharmaceutical composition thereof, wherein the structure of the amide compound is represented by a general formula (I). According to the present invention, the amide compound (I) can regulate GPR40 activity, and can be used for GPR40 activity related diseases such as diabetes and metabolic syndrome. The formula I is defined in the specification.
Synthesis, antibacterial activity, and docking studies of some new 2-substituted-1,8-naphthyridine derivatives
Vijaya Bhasker,Satyanarayana,Laxminarayana,Latha,Thirumala Chary
, p. 227 - 242 (2018/09/14)
1,8-Naphthyridine derivatives play a very important role in the field of medicinal chemistry. 2 series of novel 2-substituted-1,8-naphthyridine derivatives (10a-10k and 15a-15e) were synthesized. All the synthesized compounds were characterized by1H nuclear magnetic resonance (NMR),13C NMR, mass, and IR spectral analysis. Further, these compounds were evaluated for their antibacterial activity. Docking studies for these title compounds are also presented in this communication.
PYRIMIDINONE DERIVATIVE HAVING AUTOTAXIN-INHIBITORY ACTIVITY
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Paragraph 0763; 0764, (2017/07/05)
A compound according to any one of formula (Ia) to (Ic), or its pharmaceutically acceptable salt: wherein R1, R2, R3, R4a, R4c, R5 are as defined in the description.
Expedient solution-phase synthesis and NMR studies of arylopeptoids
Hjelmgaard, Thomas,Faure, Sophie,Staerk, Dan,Taillefumier, Claude,Nielsen, John
experimental part, p. 4121 - 4132 (2011/09/20)
The development of a highly convenient and efficient protocol for iterative solution-phase synthesis of shorter oligomers of para-and meta-arylopeptoids is described. Peptide coupling methods for accessing longer oligomers were studied: use of the new cou
NITROGEN-CONTAINING HETEROARYL DERIVATIVES
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Page 37-38, (2010/02/09)
Disclosed are compounds, compositions and methods for treating Flaviviridae family virus infections.
Parallel synthesis of glycomimetic libraries: targeting a C-type lectin.
Schuster, Michael C,Mann, David A,Buchholz, Tonia J,Johnson, Kathryn M,Thomas, William D,Kiessling, Laura L
, p. 1407 - 1410 (2007/10/03)
We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogues of mannose on a solid support. The natural product shikimic acid was used as a key building block. The ability of the compounds to block the binding of the C-type lectin MBP-A to a mannosylated surface was assessed in a high-throughput assay. Ten library members with inhibitory activities equivalent to that of alpha-methyl mannopyranoside were identified. [reaction: see text]
Protease inhibitors
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, (2008/06/13)
The present invention provides compounds of formula (I) which inhibit proteases, including cathepsin K, pharmaceutical compositions of such compounds, and methods for treating diseases of excessive bone loss or cartilage or matrix degradation, including osteoporosis; gingival disease including gingivitis and periodontitis; arthritis, more specifically, osteoarthritis and rheumatoid arthritis; Paget's disease; hypercalcemia or malignancy; and metabolic bone disease therewith.
Pyrimidin derivatives
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, (2008/06/13)
The invention relates to new pharmaceutically active compounds which are are P2-purinoceptor 7-transmembrane (TM) G-protein coupled receptor antagonists, compositions containing them and processes for their preparation.
Analogs of tyrosine sulfate or tyrosine phosphate containing peptides
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, (2008/06/13)
Analogs of Tyrosine Sulfate or Tyrosine Phosphate containing peptides, the novel intermediate compounds used in the preparation of these analogs, as well as a method for suppressing appetite in subjects by administering to the subject an effective amount
